Effect of leukotriene D4 on blood flow to cerebrum and choroid plexus

W. G. Mayhan, F. M. Faraci, R. Spector, D. D. Heistad

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3 Scopus citations

Abstract

The purpose of this study was to examine effects of leukotriene D4 on blood flow to the cerebrum and choroid plexus. Blood flow was measured with microspheres in anesthetized rabbits. Under control conditions, blood flow to the cerebrum was 37 ± 4 ml · min-1 · 100 g-a1 (mean ± SE) and blood flow to the choroid plexus was 428 ± 52 ml · min-1 · 100 g-1. Intra-atrial infusion of leukotriene D4 at 0.1 and 1.0 μg · kg-1 · min-1 did not alter blood flow to the brain or choroid plexus, but produced a 49 ± 3% and 69 ± 5% decrease in blood flow to the bowel. We also examined effects of intracerebroventricular administration of leukotriene D4. Intraventricular injection of 1.0 μg of leukotriene D4 did not affect blood flow to the cerebrum or choroid plexus. In contrast, intraventricular injection of 1.0 μg of angiotensin II produced a 42 ± 4% decrease in blood flow to the choroid plexus. In summary, neither intravenous nor intraventricular administration of leukotriene D4 affects blood flow to the brain or choroid plexus.

Original languageEnglish (US)
Pages (from-to)H834-H838
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume257
Issue number3 (26/3)
DOIs
StatePublished - Jan 1 1989

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ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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