Effect of laparoscopic antireflux surgery upon renal blood flow

Chandrakanth Are, Michael Kutka, Mark Talamini, Jeffrey Hardacre, Mario Mendoza-Sagaon, Eric Hanley, Thomas Toung

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Hypercapnia and local pressure effects unique to CO2 base minimally invasive surgery alter renal blood flow. We have demonstrated laparoscopic antireflux surgery to have an additional impact upon hemodynamics (decreased cardiac output), potentially extending known effects upon renal blood flow. Methods: We measured renal blood flow with radioactive microspheres during laparoscopic antireflux surgery in a porcine model. Six pigs were anesthetized, monitoring lines were placed, and microspheres injected five time points associated with a laparoscopic antireflux operation. After euthanasia kidneys were retrieved and fixed, and representative samples counted for radioactivity specific for each of the five time points. Results: The greatest reduction in renal blood flow was 36% below baseline (p<0.05). Concurrently, cardiac output had a maximum reduction of 39%. Conclusions: Laparoscopic Nissen fundoplication in this pig model is associated with a significant reduction in renal blood flow, probably related to reduction in cardiac output. Caution is warranted when considering laparoscopic antireflux surgery in patients with a compromised renal blood flow.

Original languageEnglish (US)
Pages (from-to)419-423
Number of pages5
JournalAmerican journal of surgery
Volume183
Issue number4
DOIs
StatePublished - Jan 1 2002

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Renal Circulation
Laparoscopy
Cardiac Output
Swine
Microspheres
Fundoplication
Euthanasia
Minimally Invasive Surgical Procedures
Hypercapnia
Radioactivity
Hemodynamics
Kidney
Pressure

ASJC Scopus subject areas

  • Surgery

Cite this

Are, C., Kutka, M., Talamini, M., Hardacre, J., Mendoza-Sagaon, M., Hanley, E., & Toung, T. (2002). Effect of laparoscopic antireflux surgery upon renal blood flow. American journal of surgery, 183(4), 419-423. https://doi.org/10.1016/S0002-9610(02)00824-3

Effect of laparoscopic antireflux surgery upon renal blood flow. / Are, Chandrakanth; Kutka, Michael; Talamini, Mark; Hardacre, Jeffrey; Mendoza-Sagaon, Mario; Hanley, Eric; Toung, Thomas.

In: American journal of surgery, Vol. 183, No. 4, 01.01.2002, p. 419-423.

Research output: Contribution to journalArticle

Are, C, Kutka, M, Talamini, M, Hardacre, J, Mendoza-Sagaon, M, Hanley, E & Toung, T 2002, 'Effect of laparoscopic antireflux surgery upon renal blood flow', American journal of surgery, vol. 183, no. 4, pp. 419-423. https://doi.org/10.1016/S0002-9610(02)00824-3
Are C, Kutka M, Talamini M, Hardacre J, Mendoza-Sagaon M, Hanley E et al. Effect of laparoscopic antireflux surgery upon renal blood flow. American journal of surgery. 2002 Jan 1;183(4):419-423. https://doi.org/10.1016/S0002-9610(02)00824-3
Are, Chandrakanth ; Kutka, Michael ; Talamini, Mark ; Hardacre, Jeffrey ; Mendoza-Sagaon, Mario ; Hanley, Eric ; Toung, Thomas. / Effect of laparoscopic antireflux surgery upon renal blood flow. In: American journal of surgery. 2002 ; Vol. 183, No. 4. pp. 419-423.
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AU - Hanley, Eric

AU - Toung, Thomas

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