Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum

Ghribi Othman, Jacques Callebert, Michel Plotkine, Roger G. Boulu

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined the effect of kynurenic acid, a broad spectrum antagonist of excitatory amino acid receptors, on striatal extracellular glutamate and aspartate accumulation induced by a 30 min forebrain ischaemia in rats. Kynurenic acid, given systemically (500 mg kg-1, i.p.) or administered in situ through the dialysis probe (10 mM), markedly depressed the ischaemia-induced increase in glutamate and aspartate concentrations. These results indicate that, during forebrain ischaemia, local glutamate receptors play a major role in glutamate and aspartate accumulation in the striatum. Ischaemia-induced increase in extracellular concentrations of these excitatory amino acids may be due in part to a positive glutamatergic feedback loop via activation of NMDA and/or non-NMDA receptors.

Original languageEnglish (US)
Pages (from-to)435-437
Number of pages3
JournalNeuroReport
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1994

Fingerprint

Kynurenic Acid
Glutamic Acid
Ischemia
Aspartic Acid
Glutamate Receptors
Prosencephalon
Corpus Striatum
Excitatory Amino Acids
N-Methylaspartate
Dialysis

Keywords

  • Aspartate
  • Glutamate
  • Ischaemia
  • Kynurenic acid
  • Microdialysis
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum. / Othman, Ghribi; Callebert, Jacques; Plotkine, Michel; Boulu, Roger G.

In: NeuroReport, Vol. 5, No. 4, 01.01.1994, p. 435-437.

Research output: Contribution to journalArticle

Othman, Ghribi ; Callebert, Jacques ; Plotkine, Michel ; Boulu, Roger G. / Effect of kynurenic acid on the ischaemia-induced accumulation of glutamate in rat striatum. In: NeuroReport. 1994 ; Vol. 5, No. 4. pp. 435-437.
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