Abstract
Invariant chain (Ii) binds to the human leukocyte antigen (HLA) class II molecule and assists it in the process of peptide acquisition. In addition, Ii binds to the HLA class I molecule, although there has been little study of its effects on the HLA class I molecule. In addition to its normal expression on antigen-presenting cells, Ii expression is up regulated in a variety of tumors. By flow cytometric analysis, we found that expression of Ii resulted in an increase in the number of cell surface HLA class I molecules and in the proportion of unstable HLA class I molecules at the surface of breast tumor cell lines. These data suggest that the expression of Ii by tumor cells may quantitatively and qualitatively alter the presentation of antigens on those cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 729-736 |
| Number of pages | 8 |
| Journal | Cancer Immunology, Immunotherapy |
| Volume | 58 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2009 |
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Keywords
- Antigen presentation
- Antigens/peptides/epitopes
- Breast cancer
- Invariant chain
- MHC class I molecule
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Oncology
- Cancer Research
Cite this
Effect of invariant chain on major histocompatibility complex class i molecule expression and stability on human breast tumor cell lines. / Lin, Xuede; Wang, Xiaojian; Capek, Haley L.; Simone, Laura C.; Tuli, Amit; Morris, Chantey R.; Reber, Adrian J.; Solheim, Joyce C.
In: Cancer Immunology, Immunotherapy, Vol. 58, No. 5, 01.05.2009, p. 729-736.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of invariant chain on major histocompatibility complex class i molecule expression and stability on human breast tumor cell lines
AU - Lin, Xuede
AU - Wang, Xiaojian
AU - Capek, Haley L.
AU - Simone, Laura C.
AU - Tuli, Amit
AU - Morris, Chantey R.
AU - Reber, Adrian J.
AU - Solheim, Joyce C
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Invariant chain (Ii) binds to the human leukocyte antigen (HLA) class II molecule and assists it in the process of peptide acquisition. In addition, Ii binds to the HLA class I molecule, although there has been little study of its effects on the HLA class I molecule. In addition to its normal expression on antigen-presenting cells, Ii expression is up regulated in a variety of tumors. By flow cytometric analysis, we found that expression of Ii resulted in an increase in the number of cell surface HLA class I molecules and in the proportion of unstable HLA class I molecules at the surface of breast tumor cell lines. These data suggest that the expression of Ii by tumor cells may quantitatively and qualitatively alter the presentation of antigens on those cells.
AB - Invariant chain (Ii) binds to the human leukocyte antigen (HLA) class II molecule and assists it in the process of peptide acquisition. In addition, Ii binds to the HLA class I molecule, although there has been little study of its effects on the HLA class I molecule. In addition to its normal expression on antigen-presenting cells, Ii expression is up regulated in a variety of tumors. By flow cytometric analysis, we found that expression of Ii resulted in an increase in the number of cell surface HLA class I molecules and in the proportion of unstable HLA class I molecules at the surface of breast tumor cell lines. These data suggest that the expression of Ii by tumor cells may quantitatively and qualitatively alter the presentation of antigens on those cells.
KW - Antigen presentation
KW - Antigens/peptides/epitopes
KW - Breast cancer
KW - Invariant chain
KW - MHC class I molecule
UR - http://www.scopus.com/inward/record.url?scp=61349113974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=61349113974&partnerID=8YFLogxK
U2 - 10.1007/s00262-008-0595-1
DO - 10.1007/s00262-008-0595-1
M3 - Article
C2 - 18828016
AN - SCOPUS:61349113974
VL - 58
SP - 729
EP - 736
JO - Cancer Immunology and Immunotherapy
JF - Cancer Immunology and Immunotherapy
SN - 0340-7004
IS - 5
ER -