Effect of intraocular pressure on uveoscleral outflow following cyclodialysis in the monkey eye

C. B. Toris, J. E. Pederson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 ± 0.8 to 7.1 to 7.1 ± 1.4 mm Hg (P < 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the other at 4 mm HJ. Four pairs of control eyes (without cyclodialysis) were perfused in the same manner. At 4 mm Hg, uveoscleral outflow was 0.02 ± 0.02 μl/min in control eyes and 0.05 ± 0.04 μl/min in eyes following cyclodialysis. However, at 35 mm Hg, uveoscleral outflow in eyes with cyclodialysis increased to 2.13 ± 0.47 μl/min compared to 0.32 ± 0.10 μl/min in control eyes. Thus the 'facility' of uveoscleral outflow in control eyes is 0.01 μl/min/mm Hg and in eyes following cyclodialysis is 0.07 μl/min/mm Hg. It is concluded that cyclodialysis results in a pressure-dependent increase in uveoscleral outflow.

Original languageEnglish (US)
Pages (from-to)1745-1749
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume26
Issue number12
StatePublished - Dec 1 1985

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Intraocular Pressure
Haplorhini
Macaca fascicularis
Dextrans
Pressure

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Effect of intraocular pressure on uveoscleral outflow following cyclodialysis in the monkey eye. / Toris, C. B.; Pederson, J. E.

In: Investigative Ophthalmology and Visual Science, Vol. 26, No. 12, 01.12.1985, p. 1745-1749.

Research output: Contribution to journalArticle

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abstract = "Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 ± 0.8 to 7.1 to 7.1 ± 1.4 mm Hg (P < 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the other at 4 mm HJ. Four pairs of control eyes (without cyclodialysis) were perfused in the same manner. At 4 mm Hg, uveoscleral outflow was 0.02 ± 0.02 μl/min in control eyes and 0.05 ± 0.04 μl/min in eyes following cyclodialysis. However, at 35 mm Hg, uveoscleral outflow in eyes with cyclodialysis increased to 2.13 ± 0.47 μl/min compared to 0.32 ± 0.10 μl/min in control eyes. Thus the 'facility' of uveoscleral outflow in control eyes is 0.01 μl/min/mm Hg and in eyes following cyclodialysis is 0.07 μl/min/mm Hg. It is concluded that cyclodialysis results in a pressure-dependent increase in uveoscleral outflow.",
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N2 - Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 ± 0.8 to 7.1 to 7.1 ± 1.4 mm Hg (P < 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the other at 4 mm HJ. Four pairs of control eyes (without cyclodialysis) were perfused in the same manner. At 4 mm Hg, uveoscleral outflow was 0.02 ± 0.02 μl/min in control eyes and 0.05 ± 0.04 μl/min in eyes following cyclodialysis. However, at 35 mm Hg, uveoscleral outflow in eyes with cyclodialysis increased to 2.13 ± 0.47 μl/min compared to 0.32 ± 0.10 μl/min in control eyes. Thus the 'facility' of uveoscleral outflow in control eyes is 0.01 μl/min/mm Hg and in eyes following cyclodialysis is 0.07 μl/min/mm Hg. It is concluded that cyclodialysis results in a pressure-dependent increase in uveoscleral outflow.

AB - Cyclodialysis was performed in both eyes of five cynomolgus monkeys. Two days later the intraocular pressure (IOP) had fallen from 17.7 ± 0.8 to 7.1 to 7.1 ± 1.4 mm Hg (P < 0.001). At that time, both eyes were perfused for 30 min with fluorescein-isothiocyanate (FITC) dextran (MW 70,000), one at 35 mm Hg and the other at 4 mm HJ. Four pairs of control eyes (without cyclodialysis) were perfused in the same manner. At 4 mm Hg, uveoscleral outflow was 0.02 ± 0.02 μl/min in control eyes and 0.05 ± 0.04 μl/min in eyes following cyclodialysis. However, at 35 mm Hg, uveoscleral outflow in eyes with cyclodialysis increased to 2.13 ± 0.47 μl/min compared to 0.32 ± 0.10 μl/min in control eyes. Thus the 'facility' of uveoscleral outflow in control eyes is 0.01 μl/min/mm Hg and in eyes following cyclodialysis is 0.07 μl/min/mm Hg. It is concluded that cyclodialysis results in a pressure-dependent increase in uveoscleral outflow.

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