Effect of interferon‐gamma priming on the activation of murine peritoneal macrophages to tumouricidal state by cisplatin, IL‐1, and tumour necrosis factor (TNF)

production of IL‐1 and TNF

A. SODHI, Rakesh K Singh, S. M. SINGH

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The effect of interferon‐gamma (IFN‐γ) priming of murine peritoneal macrophages on the activation to tumouricidal state by cisplatin. lipopolysaccharide (LPS)‐IL‐1 and TNF was investigated. Cisplatin‐, LPS‐, IL‐1‐ or TNF‐treated IFN‐γ‐primed macrophages showed significantly enhanced tumouricidal activity and binding to tumour cells, compared with unprimed treated or untreated macrophages. Macrophages treated with cisplatin, LPS, IL‐1 and TNF produced released and membrane‐associated IL‐1 and TNF activity which was significantly enhanced after priming with IFN‐γ. These observations suggest the use of IFN‐γ along with these biological response modifiers in designing immunotherapeutic protocols for treatment of malignancy.

Original languageEnglish (US)
Pages (from-to)350-355
Number of pages6
JournalClinical & Experimental Immunology
Volume88
Issue number2
DOIs
StatePublished - Jan 1 1992

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Peritoneal Macrophages
Cisplatin
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Macrophages
Macrophage Activation
Immunologic Factors
Clinical Protocols
Neoplasms

Keywords

  • IL‐1
  • cytotoxicity
  • interferon‐gamma
  • macrophages
  • tumour necrosis factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

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abstract = "The effect of interferon‐gamma (IFN‐γ) priming of murine peritoneal macrophages on the activation to tumouricidal state by cisplatin. lipopolysaccharide (LPS)‐IL‐1 and TNF was investigated. Cisplatin‐, LPS‐, IL‐1‐ or TNF‐treated IFN‐γ‐primed macrophages showed significantly enhanced tumouricidal activity and binding to tumour cells, compared with unprimed treated or untreated macrophages. Macrophages treated with cisplatin, LPS, IL‐1 and TNF produced released and membrane‐associated IL‐1 and TNF activity which was significantly enhanced after priming with IFN‐γ. These observations suggest the use of IFN‐γ along with these biological response modifiers in designing immunotherapeutic protocols for treatment of malignancy.",
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