Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats

Jon A. Vanderhoof, Michael J. Metz, Dean J. Tuma, Dean L. Antonson, Michael Floyd Sorrell

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Jejunoileal bypasses were performed in rats to determine the effect of improved absorption on the development of liver dysfunction occurring after this procedure. Several parameters of liver function were measured in rats 7 weeks after both the standard 85% small-bowel, bypass and an 80% bypass in which an extra 5 cm of intact bowel was retained. Animals having undergone 80% bypass had a lesser degree of lowering of serum protein and triglyceride levels, hepatic cytochrome P-450 content, and hepatic glucose-6-phosphatase activity than did the animals undergoing 85% bypass. Abnormalities found in 85% bypassed animals were only partially reproduced by reducing food intake in another group of 80% bypassed animals. These findings emphasize the importance of, nutritional factors in the etiology of bypass-induced liver disease and militate against toxin production in the defunctionalized bowel as the sole cause of liver dysfunction following bypass.

Original languageEnglish (US)
Pages (from-to)581-586
Number of pages6
JournalDigestive Diseases and Sciences
Volume25
Issue number8
DOIs
StatePublished - Aug 1 1980

Fingerprint

Jejunoileal Bypass
Liver Diseases
Liver
Glucose-6-Phosphatase
Cytochrome P-450 Enzyme System
Blood Proteins
Triglycerides
Eating

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats. / Vanderhoof, Jon A.; Metz, Michael J.; Tuma, Dean J.; Antonson, Dean L.; Sorrell, Michael Floyd.

In: Digestive Diseases and Sciences, Vol. 25, No. 8, 01.08.1980, p. 581-586.

Research output: Contribution to journalArticle

Vanderhoof, Jon A. ; Metz, Michael J. ; Tuma, Dean J. ; Antonson, Dean L. ; Sorrell, Michael Floyd. / Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats. In: Digestive Diseases and Sciences. 1980 ; Vol. 25, No. 8. pp. 581-586.
@article{34d136ea8e36413ba84f8be9f8373246,
title = "Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats",
abstract = "Jejunoileal bypasses were performed in rats to determine the effect of improved absorption on the development of liver dysfunction occurring after this procedure. Several parameters of liver function were measured in rats 7 weeks after both the standard 85{\%} small-bowel, bypass and an 80{\%} bypass in which an extra 5 cm of intact bowel was retained. Animals having undergone 80{\%} bypass had a lesser degree of lowering of serum protein and triglyceride levels, hepatic cytochrome P-450 content, and hepatic glucose-6-phosphatase activity than did the animals undergoing 85{\%} bypass. Abnormalities found in 85{\%} bypassed animals were only partially reproduced by reducing food intake in another group of 80{\%} bypassed animals. These findings emphasize the importance of, nutritional factors in the etiology of bypass-induced liver disease and militate against toxin production in the defunctionalized bowel as the sole cause of liver dysfunction following bypass.",
author = "Vanderhoof, {Jon A.} and Metz, {Michael J.} and Tuma, {Dean J.} and Antonson, {Dean L.} and Sorrell, {Michael Floyd}",
year = "1980",
month = "8",
day = "1",
doi = "10.1007/BF01318870",
language = "English (US)",
volume = "25",
pages = "581--586",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "8",

}

TY - JOUR

T1 - Effect of improved absorption on development of jejunoileal bypass-induced liver dysfunction in rats

AU - Vanderhoof, Jon A.

AU - Metz, Michael J.

AU - Tuma, Dean J.

AU - Antonson, Dean L.

AU - Sorrell, Michael Floyd

PY - 1980/8/1

Y1 - 1980/8/1

N2 - Jejunoileal bypasses were performed in rats to determine the effect of improved absorption on the development of liver dysfunction occurring after this procedure. Several parameters of liver function were measured in rats 7 weeks after both the standard 85% small-bowel, bypass and an 80% bypass in which an extra 5 cm of intact bowel was retained. Animals having undergone 80% bypass had a lesser degree of lowering of serum protein and triglyceride levels, hepatic cytochrome P-450 content, and hepatic glucose-6-phosphatase activity than did the animals undergoing 85% bypass. Abnormalities found in 85% bypassed animals were only partially reproduced by reducing food intake in another group of 80% bypassed animals. These findings emphasize the importance of, nutritional factors in the etiology of bypass-induced liver disease and militate against toxin production in the defunctionalized bowel as the sole cause of liver dysfunction following bypass.

AB - Jejunoileal bypasses were performed in rats to determine the effect of improved absorption on the development of liver dysfunction occurring after this procedure. Several parameters of liver function were measured in rats 7 weeks after both the standard 85% small-bowel, bypass and an 80% bypass in which an extra 5 cm of intact bowel was retained. Animals having undergone 80% bypass had a lesser degree of lowering of serum protein and triglyceride levels, hepatic cytochrome P-450 content, and hepatic glucose-6-phosphatase activity than did the animals undergoing 85% bypass. Abnormalities found in 85% bypassed animals were only partially reproduced by reducing food intake in another group of 80% bypassed animals. These findings emphasize the importance of, nutritional factors in the etiology of bypass-induced liver disease and militate against toxin production in the defunctionalized bowel as the sole cause of liver dysfunction following bypass.

UR - http://www.scopus.com/inward/record.url?scp=0018823512&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018823512&partnerID=8YFLogxK

U2 - 10.1007/BF01318870

DO - 10.1007/BF01318870

M3 - Article

VL - 25

SP - 581

EP - 586

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 8

ER -