Effect of High Percentage Medium-Chain Triglyceride Diet on Mucosal Adaptation following Massive Bowel Resection in Rats

Jon A. Vanderhoof, Carter J. Grandjean, Stuart S. Kaufman, Karen T. Burkley, Dean L. Antonson

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Patients undergoing massive small bowel resection for a variety of conditions develop severe nutrient malabsorption which gradually improves through mucosal hyperplasia in the remaining small intestine. Following massive small bowel resection, patients are generally fed elemental diets, often containing high concentrations of medium-chain triglycerides. We evaluated the effect of high percentage medium-chain triglyceride feeding on mucosal adaptation following massive small bowel resection in rats. Twenty 150-g Sprague-Dawley rats were subjected to 60% jejunoileal resection. Another 20 animals received sham operations. One-half of each group were fed a diet containing 83% of the fat as medium-chain triglycerides, the remainder were fed a diet containing 40% medium-chain triglycerides. Animals were pair-fed for 2 wk and subsequently killed. The remaining bowel was removed and unidirectional glucose and leucine uptake were measured using isolated sacs. Mucosal wet weight, protein, and sucrase content were determined. Animals fed medium-chain triglycerides demonstrated decreased mucosal weight in the proximal bowel, decreased mucosal sucrase activity in the proximal bowel, and decreased mucosal leucine uptake in the distal bowel. While medium-chain triglycerides offer an advantage to patients with short bowel syndrome because they are easily absorbed, they may not stimulate the same degree of mucosal adaptation following resection as long-chain triglyceride feedings. (Journal of Parenteral and Enteral Nutrition 8:685-689, 1984).

Original languageEnglish (US)
Pages (from-to)685-689
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume8
Issue number6
DOIs
StatePublished - Nov 1984

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Triglycerides
Diet
Sucrase
Leucine
Short Bowel Syndrome
Formulated Food
Weights and Measures
Parenteral Nutrition
Enteral Nutrition
Small Intestine
Hyperplasia
Sprague Dawley Rats
Fats
Glucose
Food
Proteins

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of High Percentage Medium-Chain Triglyceride Diet on Mucosal Adaptation following Massive Bowel Resection in Rats. / Vanderhoof, Jon A.; Grandjean, Carter J.; Kaufman, Stuart S.; Burkley, Karen T.; Antonson, Dean L.

In: Journal of Parenteral and Enteral Nutrition, Vol. 8, No. 6, 11.1984, p. 685-689.

Research output: Contribution to journalArticle

Vanderhoof, Jon A. ; Grandjean, Carter J. ; Kaufman, Stuart S. ; Burkley, Karen T. ; Antonson, Dean L. / Effect of High Percentage Medium-Chain Triglyceride Diet on Mucosal Adaptation following Massive Bowel Resection in Rats. In: Journal of Parenteral and Enteral Nutrition. 1984 ; Vol. 8, No. 6. pp. 685-689.
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