Effect of ethanol and its metabolites on microtubule formation

R. B. Jennett, D. J. Tuma, Michael Floyd Sorrell

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

Original languageEnglish (US)
Pages (from-to)363-368
Number of pages6
JournalPharmacology
Volume21
Issue number5
DOIs
StatePublished - Jan 1 1980

Fingerprint

Microtubules
Polymerization
Acetaldehyde
Ethanol
Tubulin
Acetates
Sodium Acetate
Sodium Chloride

Keywords

  • Acetaldehyde
  • Acetate
  • Ethanol
  • Microtubules
  • Tubulin polymerization

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of ethanol and its metabolites on microtubule formation. / Jennett, R. B.; Tuma, D. J.; Sorrell, Michael Floyd.

In: Pharmacology, Vol. 21, No. 5, 01.01.1980, p. 363-368.

Research output: Contribution to journalArticle

Jennett, R. B. ; Tuma, D. J. ; Sorrell, Michael Floyd. / Effect of ethanol and its metabolites on microtubule formation. In: Pharmacology. 1980 ; Vol. 21, No. 5. pp. 363-368.
@article{eb47761013da41ab8c5b78000d809a5c,
title = "Effect of ethanol and its metabolites on microtubule formation",
abstract = "Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.",
keywords = "Acetaldehyde, Acetate, Ethanol, Microtubules, Tubulin polymerization",
author = "Jennett, {R. B.} and Tuma, {D. J.} and Sorrell, {Michael Floyd}",
year = "1980",
month = "1",
day = "1",
doi = "10.1159/000137453",
language = "English (US)",
volume = "21",
pages = "363--368",
journal = "Pharmacology",
issn = "0031-7012",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Effect of ethanol and its metabolites on microtubule formation

AU - Jennett, R. B.

AU - Tuma, D. J.

AU - Sorrell, Michael Floyd

PY - 1980/1/1

Y1 - 1980/1/1

N2 - Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

AB - Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetaldehyde inhibited tubulin polymerization in a concentration-dependent manner, with complete inhibition at 10 mM and slight inhibition at 1 mM. Sodium acetate caused a concentration-dependent increase in tubulin polymerization, however sodium chloride showed a similar effect. These data indicate that ethanol and acetate were not inhibitors of microtubule formation while acetaldehyde exhibited weak inhibitory activity.

KW - Acetaldehyde

KW - Acetate

KW - Ethanol

KW - Microtubules

KW - Tubulin polymerization

UR - http://www.scopus.com/inward/record.url?scp=0018966073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018966073&partnerID=8YFLogxK

U2 - 10.1159/000137453

DO - 10.1159/000137453

M3 - Article

C2 - 7433516

AN - SCOPUS:0018966073

VL - 21

SP - 363

EP - 368

JO - Pharmacology

JF - Pharmacology

SN - 0031-7012

IS - 5

ER -