Effect of dual tocolysis on the incidence of severe intraventricular hemorrhage among extremely low-birth-weight infants

T. A. Iannucci, R. E. Besinger, S. G. Fisher, J. G. Gianopoulos, P. G. Tomich

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

OBJECTIVE: Our purpose was to evaluate the null hypothesis that dual tocolysis with magnesium sulfate and indomethacin does not alter the rate of grade III or IV intraventricular hemorrhage. STUDY DESIGN: Fifty-six neonates weighing 500 to 800 gm from mothers who received tocolytic therapy with magnesium sulfate alone or in combination with indomethacin were the subjects of this retrospective study. Demographic variables were evaluated with a Student t test, χ2 analysis, Fisher exact test, or Mantel-Haenszel χ2 as appropriate. RESULTS: There was an increased incidence of grade III to IV intraventricular hemorrhage among patients treated with dual therapy (p = 0.02). Logistic regression showed that fetal age and dual tocolysis with indomethacin were the only independent prognostic factors for severe intraventricular hemorrhage. CONCLUSION: The results indicate that dual tocolysis with indomethacin may place extremely low-birth-weight infants at increased risk for grade III to IV intraventricular hemorrhage.

Original languageEnglish (US)
Pages (from-to)1043-1046
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume175
Issue number4 I
DOIs
StatePublished - Jan 1 1996

Fingerprint

Extremely Low Birth Weight Infant
Tocolysis
Indomethacin
Hemorrhage
Magnesium Sulfate
Incidence
Gestational Age
Retrospective Studies
Logistic Models
Mothers
Demography
Newborn Infant
Students

Keywords

  • Premature labor
  • extremely low birth weight
  • indomethacin
  • intraventricular hemorrhage
  • tocolytic

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Effect of dual tocolysis on the incidence of severe intraventricular hemorrhage among extremely low-birth-weight infants. / Iannucci, T. A.; Besinger, R. E.; Fisher, S. G.; Gianopoulos, J. G.; Tomich, P. G.

In: American Journal of Obstetrics and Gynecology, Vol. 175, No. 4 I, 01.01.1996, p. 1043-1046.

Research output: Contribution to journalArticle

Iannucci, T. A. ; Besinger, R. E. ; Fisher, S. G. ; Gianopoulos, J. G. ; Tomich, P. G. / Effect of dual tocolysis on the incidence of severe intraventricular hemorrhage among extremely low-birth-weight infants. In: American Journal of Obstetrics and Gynecology. 1996 ; Vol. 175, No. 4 I. pp. 1043-1046.
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