Effect of dual tocolysis on the incidence of severe intraventricular hemorrhage among extremely low-birth-weight infants

T. A. Iannucci, R. E. Besinger, S. G. Fisher, J. G. Gianopoulos, P. G. Tomich

Research output: Contribution to journalArticle

21 Scopus citations


OBJECTIVE: Our purpose was to evaluate the null hypothesis that dual tocolysis with magnesium sulfate and indomethacin does not alter the rate of grade III or IV intraventricular hemorrhage. STUDY DESIGN: Fifty-six neonates weighing 500 to 800 gm from mothers who received tocolytic therapy with magnesium sulfate alone or in combination with indomethacin were the subjects of this retrospective study. Demographic variables were evaluated with a Student t test, χ2 analysis, Fisher exact test, or Mantel-Haenszel χ2 as appropriate. RESULTS: There was an increased incidence of grade III to IV intraventricular hemorrhage among patients treated with dual therapy (p = 0.02). Logistic regression showed that fetal age and dual tocolysis with indomethacin were the only independent prognostic factors for severe intraventricular hemorrhage. CONCLUSION: The results indicate that dual tocolysis with indomethacin may place extremely low-birth-weight infants at increased risk for grade III to IV intraventricular hemorrhage.

Original languageEnglish (US)
Pages (from-to)1043-1046
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Issue number4 I
Publication statusPublished - Jan 1 1996



  • Premature labor
  • extremely low birth weight
  • indomethacin
  • intraventricular hemorrhage
  • tocolytic

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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