Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model

Parviz M. Pour, Terence A Lawson, Scott Helgeson, Thorkatla Donnelly, Katherin Stepan

Research output: Contribution to journalArticle

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Abstract

To examine the effect of cholecystokinin (CCK) on pancreatic carcinogenicity in the hamster model, two sets of experiments were carried out. In one study, CCK (20 IDU/kg body wt) was given 3 h before, simultaneously with or 3 h after a single dose (20 mg/kg body wt) of N-nitrosobis(2-oxopropyl)amine (BOP). In another experiment, hamsters were treated similarly except that both CCK (20 IDU/kg body wt) and BOP (2.5 mg/kg body wt) were given weekly for 20 weeks. The results showed that CCK in the first experiment (single BOP dose) inhibited pancreatic cancer induction in a statistically significant fashion when given either 3 h prior to (P<0.05) or simultaneously with BOP (P<0.0005); however, CCK, when administered after BOP did not alter the cancer incidence as compared with hamsters treated with BOP alone. In the second experiment (chronic BOP treatment) the pattern and the incidence of pancreatic tumors were not affected by CCK.

Original languageEnglish (US)
Pages (from-to)597-601
Number of pages5
JournalCarcinogenesis
Volume9
Issue number4
DOIs
StatePublished - Apr 1 1988

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Cholecystokinin
Cricetinae
Carcinogenesis
nitrosobis(2-oxopropyl)amine
Incidence
Pancreatic Neoplasms
Neoplasms

ASJC Scopus subject areas

  • Cancer Research

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Pour, P. M., Lawson, T. A., Helgeson, S., Donnelly, T., & Stepan, K. (1988). Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model. Carcinogenesis, 9(4), 597-601. https://doi.org/10.1093/carcin/9.4.597

Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model. / Pour, Parviz M.; Lawson, Terence A; Helgeson, Scott; Donnelly, Thorkatla; Stepan, Katherin.

In: Carcinogenesis, Vol. 9, No. 4, 01.04.1988, p. 597-601.

Research output: Contribution to journalArticle

Pour, PM, Lawson, TA, Helgeson, S, Donnelly, T & Stepan, K 1988, 'Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model', Carcinogenesis, vol. 9, no. 4, pp. 597-601. https://doi.org/10.1093/carcin/9.4.597
Pour, Parviz M. ; Lawson, Terence A ; Helgeson, Scott ; Donnelly, Thorkatla ; Stepan, Katherin. / Effect of cholecystokinin on pancreatic carcinogenesis in the hamster model. In: Carcinogenesis. 1988 ; Vol. 9, No. 4. pp. 597-601.
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