Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery

Constantine T. Frantzides, Mark Alan Carlson, Ronald E. Moore, John G. Zografakis, Atul K. Madan, Susan Puumala, Ali Keshavarzian

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The risk factors for nonalcoholic fatty liver disease in patients undergoing bariatric surgery are under study. We wanted to determine the correlation between nonalcoholic fatty liver disease and patient factors such as obesity and liver function tests. A retrospective analysis was performed on 177 nonalcoholic morbidly obese patients who underwent laparoscopic Roux-en-Y gastric bypass with liver biopsy, to identify risk factors for nonalcoholic fatty liver disease. The histologic grade of liver disease was compared with preoperative body mass index, age, and liver function tests. Simple steatosis and steatohepatitis were present in 90% and 42% of patients, respectively. Elevated transaminaselevels were an independent risk for liver disease. Body mass index and liver disease were not correlated with univariate analysis. Regression analysis performed on age, body mass index, and liver disease demonstrated that the risk for liver disease increased with body mass index in the younger (<35 years old) age group and decreased with body mass index in the older (>45 years old) age group. There was a high incidence of steatosis and steatohepatitis in these nonalcoholic bariatric patients, and elevated transaminase level was indicative of disease. Body mass index was a positive risk factor for liver disease in younger patients but a negative risk factor in the older patients.

Original languageEnglish (US)
Pages (from-to)849-855
Number of pages7
JournalJournal of Gastrointestinal Surgery
Volume8
Issue number7
DOIs
StatePublished - Jan 1 2004

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Bariatric Surgery
Minimally Invasive Surgical Procedures
Body Mass Index
Liver Diseases
Liver Function Tests
Bariatrics
Gastric Bypass
Fatty Liver
Transaminases
Non-alcoholic Fatty Liver Disease
Age Groups
Obesity
Regression Analysis
Biopsy
Liver
Incidence

Keywords

  • Laparoscopic bariatric surgery
  • Morbid obesity
  • Nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. / Frantzides, Constantine T.; Carlson, Mark Alan; Moore, Ronald E.; Zografakis, John G.; Madan, Atul K.; Puumala, Susan; Keshavarzian, Ali.

In: Journal of Gastrointestinal Surgery, Vol. 8, No. 7, 01.01.2004, p. 849-855.

Research output: Contribution to journalArticle

Frantzides, Constantine T. ; Carlson, Mark Alan ; Moore, Ronald E. ; Zografakis, John G. ; Madan, Atul K. ; Puumala, Susan ; Keshavarzian, Ali. / Effect of body mass index on nonalcoholic fatty liver disease in patients undergoing minimally invasive bariatric surgery. In: Journal of Gastrointestinal Surgery. 2004 ; Vol. 8, No. 7. pp. 849-855.
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