Effect of blood group determinants on binding of human salivary mucous glycoproteins to influenza virus

Thomas F. Boat, James Davis, Robert C. Stern, Pi Wan Cheng

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have demonstrated that the inhibitor of influenza B virus hemagglutination in human saliva is inactivated by neuraminidase and is associated with the mucous glycoprotein fraction (blood group substance) of this secretion. Inhibitory activity of saliva was found to be roughly proportional to its sialic acid content (r = 0.456). However, the minimal quantity of salivary sialic acid, neutral sugar, or blood group antigen required to inhibit virus hemagglutinatino was greater of secretors of A and B than for secretors of H and Lea blood group substances. Removal of terminal galactose from blood group B substance with α-galactosidase markedly decreased blod group B activity but increased blood group H and virus hemagglutination inhibitory activities of this glycoprotein. These data suggest that terminal α-linked galactose and, probably, N-acetyl-galactosamine interfere with access of influenza virus to binding sites onn oligosaccharide chains of the mucous glycoprotein.

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalBBA - General Subjects
Volume540
Issue number1
DOIs
StatePublished - Apr 19 1978

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Blood Group Antigens
Orthomyxoviridae
Viruses
ABO Blood-Group System
Glycoproteins
Hemagglutination
N-Acetylneuraminic Acid
Galactose
Saliva
Galactosidases
Influenza B virus
Virus Attachment
Galactosamine
Neuraminidase
Oligosaccharides
Binding Sites
Sugars

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

Effect of blood group determinants on binding of human salivary mucous glycoproteins to influenza virus. / Boat, Thomas F.; Davis, James; Stern, Robert C.; Cheng, Pi Wan.

In: BBA - General Subjects, Vol. 540, No. 1, 19.04.1978, p. 127-133.

Research output: Contribution to journalArticle

Boat, Thomas F. ; Davis, James ; Stern, Robert C. ; Cheng, Pi Wan. / Effect of blood group determinants on binding of human salivary mucous glycoproteins to influenza virus. In: BBA - General Subjects. 1978 ; Vol. 540, No. 1. pp. 127-133.
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