Effect of biotin deficiency and supplementation on lipid metabolism in rats, saturated fatty acids

S. F. Suchy, William B Rizzo, B. Wolf

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The effects of biotin deficiency and supplementation upon saturated fatty acids in serum, liver, cerebrum, and cerebellum of rats were investigated. Serum total fatty acids were reduced in deficient animals to 29% of normal. The percentage composition of some odd-chain fatty acids was increased in the serum and liver of deficient rats. The relative composition of most saturated fatty acids with carbon-chain lengths ≥22 were increased in serum and liver of deficiency rats. In contrast, there were no differences in the brain saturated fatty acids of deficient animals compared to those of normal and supplemented animals. These results may indicate that alterations in saturated fatty acids to not play a major role in the neurologic abnormalities in human biotin or inherited multiple-carboxylase deficiencies.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalAmerican Journal of Clinical Nutrition
Volume44
Issue number4
DOIs
StatePublished - Jan 1 1986

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biotin
Lipid Metabolism
lipid metabolism
saturated fatty acids
Fatty Acids
rats
liver
odd chain fatty acids
Serum
animals
cerebrum
Multiple Carboxylase Deficiency
Liver
cerebellum
nervous system
Nervous System Malformations
Cerebrum
Biotin
fatty acids
brain

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of biotin deficiency and supplementation on lipid metabolism in rats, saturated fatty acids. / Suchy, S. F.; Rizzo, William B; Wolf, B.

In: American Journal of Clinical Nutrition, Vol. 44, No. 4, 01.01.1986, p. 475-480.

Research output: Contribution to journalArticle

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