Effect of an oestrogen synthesis inhibitor, 1,4,6-androstatriene-3,17-dione, on mouse embryo development in vitro

J. Sengupta, Shyamal K Roy, S. K. Manchanda

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Mouse embryos (4-8 cells) were cultured for 48 h in vitro in medium containing 1,4,6-androstatriene-3,17-dione (ATD). The inhibition of embryo development by ATD was overcome by oestradiol-17β but not by oestradiol-17α. Culture with ATD for the first and second 24 h led to normal numbers of blastocysts. The results show that preimplantation mouse embryos contain the enzymic machinery for synthesis of oestrogen.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalJournal of reproduction and fertility
Volume66
Issue number1
DOIs
StatePublished - Jan 1 1982

Fingerprint

Embryonic Development
Blastocyst
Estradiol
Cultured Cells
Estrogens
Embryonic Structures
In Vitro Techniques
androsta-1,4,6-triene-3,17-dione
Steroid Synthesis Inhibitors

ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

Effect of an oestrogen synthesis inhibitor, 1,4,6-androstatriene-3,17-dione, on mouse embryo development in vitro. / Sengupta, J.; Roy, Shyamal K; Manchanda, S. K.

In: Journal of reproduction and fertility, Vol. 66, No. 1, 01.01.1982, p. 63-66.

Research output: Contribution to journalArticle

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