Effect of an oestrogen synthesis inhibitor, 1,4,6-androstatriene-3,17-dione, on mouse embryo development in vitro

J. Sengupta, S. K. Roy, S. K. Manchanda

Research output: Contribution to journalArticle

19 Scopus citations


Mouse embryos (4-8 cells) were cultured for 48 h in vitro in medium containing 1,4,6-androstatriene-3,17-dione (ATD). The inhibition of embryo development by ATD was overcome by oestradiol-17β but not by oestradiol-17α. Culture with ATD for the first and second 24 h led to normal numbers of blastocysts. The results show that preimplantation mouse embryos contain the enzymic machinery for synthesis of oestrogen.

Original languageEnglish (US)
Pages (from-to)63-66
Number of pages4
JournalJournal of reproduction and fertility
Issue number1
Publication statusPublished - Jan 1 1982


ASJC Scopus subject areas

  • Physiology
  • Embryology
  • Molecular Biology
  • Obstetrics and Gynecology
  • Developmental Biology

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