Abstract
The onset and progression of diabetic-like retinopathy has been investigated in age-matched male beagle dogs fed a 30% galactose diet. Examination of the intact retinal vessels, isolated by gentle trypsin digestion, reveals that the destruction of pericytes to form pericyte ghosts is the earliest observable retinal vessel change. This results in an irregular distribution of endothelial cell nuclei near pericyte ghosts and the subsequent formation of acellular capillaries containing neither endothelial cells or pericytes. This was followed by the histological appearance of microaneurysms and later, by the funduscopic appearance of intraretinal hemorrhages. Studies in similar galactose-fed dogs treated with aldose reductase inhibitors indicate that all of these changes are linked to the initial aldose reductase associated destruction of pericytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 635-639 |
| Number of pages | 5 |
| Journal | Experimental Eye Research |
| Volume | 50 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1990 |
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Keywords
- aldose reductase
- aldose reductase inhibitors
- diabetes
- endothelial cells
- galactosemia
- pericytes
- retinopathy
ASJC Scopus subject areas
- Ophthalmology
- Sensory Systems
- Cellular and Molecular Neuroscience
Cite this
Effect of aldose reductase inhibitors on the progression of retinopathy in galactose-fed dogs. / Akagi, Yoshio; Kador, Peter F.
In: Experimental Eye Research, Vol. 50, No. 6, 01.01.1990, p. 635-639.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of aldose reductase inhibitors on the progression of retinopathy in galactose-fed dogs
AU - Akagi, Yoshio
AU - Kador, Peter F
PY - 1990/1/1
Y1 - 1990/1/1
N2 - The onset and progression of diabetic-like retinopathy has been investigated in age-matched male beagle dogs fed a 30% galactose diet. Examination of the intact retinal vessels, isolated by gentle trypsin digestion, reveals that the destruction of pericytes to form pericyte ghosts is the earliest observable retinal vessel change. This results in an irregular distribution of endothelial cell nuclei near pericyte ghosts and the subsequent formation of acellular capillaries containing neither endothelial cells or pericytes. This was followed by the histological appearance of microaneurysms and later, by the funduscopic appearance of intraretinal hemorrhages. Studies in similar galactose-fed dogs treated with aldose reductase inhibitors indicate that all of these changes are linked to the initial aldose reductase associated destruction of pericytes.
AB - The onset and progression of diabetic-like retinopathy has been investigated in age-matched male beagle dogs fed a 30% galactose diet. Examination of the intact retinal vessels, isolated by gentle trypsin digestion, reveals that the destruction of pericytes to form pericyte ghosts is the earliest observable retinal vessel change. This results in an irregular distribution of endothelial cell nuclei near pericyte ghosts and the subsequent formation of acellular capillaries containing neither endothelial cells or pericytes. This was followed by the histological appearance of microaneurysms and later, by the funduscopic appearance of intraretinal hemorrhages. Studies in similar galactose-fed dogs treated with aldose reductase inhibitors indicate that all of these changes are linked to the initial aldose reductase associated destruction of pericytes.
KW - aldose reductase
KW - aldose reductase inhibitors
KW - diabetes
KW - endothelial cells
KW - galactosemia
KW - pericytes
KW - retinopathy
UR - http://www.scopus.com/inward/record.url?scp=0025353463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025353463&partnerID=8YFLogxK
U2 - 10.1016/0014-4835(90)90106-5
DO - 10.1016/0014-4835(90)90106-5
M3 - Article
VL - 50
SP - 635
EP - 639
JO - Experimental Eye Research
JF - Experimental Eye Research
SN - 0014-4835
IS - 6
ER -