Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients

Gary C Yee, T. P. Lennon, D. J. Gmur, M. S. Kennedy, H. J. Deeg

Research output: Contribution to journalArticle

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Abstract

We have observed recently that infants and young children given cyclosporine (Cs) as graft-v-host disease prophylaxis usually have lower serum concentrations than adults given identical per kg doses. Studies in liver transplant recipients also indicate that Cs clearance is more rapid in children than in adults. However, data from this patient population are difficult to interpret because the liver is probably the major site of Cs metabolism. Moreover, most marrow transplant recipients receive high-dose chemotherapy either alone or combined with total body irradiation before marrow grafting, which may alter Cs metabolism during the early posttransplant period. Therefore, we analyzed the effect of age on Cs pharmacokinetics in marrow transplant recipients.

Original languageEnglish (US)
Pages (from-to)1704-1705
Number of pages2
JournalTransplantation Proceedings
Volume19
Issue number1 II
StatePublished - Apr 29 1987

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Cyclosporine
Pharmacokinetics
Bone Marrow
Whole-Body Irradiation
Liver
Transplant Recipients
Transplants
Drug Therapy
Serum
Population

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Yee, G. C., Lennon, T. P., Gmur, D. J., Kennedy, M. S., & Deeg, H. J. (1987). Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients. Transplantation Proceedings, 19(1 II), 1704-1705.

Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients. / Yee, Gary C; Lennon, T. P.; Gmur, D. J.; Kennedy, M. S.; Deeg, H. J.

In: Transplantation Proceedings, Vol. 19, No. 1 II, 29.04.1987, p. 1704-1705.

Research output: Contribution to journalArticle

Yee, GC, Lennon, TP, Gmur, DJ, Kennedy, MS & Deeg, HJ 1987, 'Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients', Transplantation Proceedings, vol. 19, no. 1 II, pp. 1704-1705.
Yee GC, Lennon TP, Gmur DJ, Kennedy MS, Deeg HJ. Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients. Transplantation Proceedings. 1987 Apr 29;19(1 II):1704-1705.
Yee, Gary C ; Lennon, T. P. ; Gmur, D. J. ; Kennedy, M. S. ; Deeg, H. J. / Effect of age on cyclosporine pharmacokinetics in marrow transplant recipients. In: Transplantation Proceedings. 1987 ; Vol. 19, No. 1 II. pp. 1704-1705.
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