Effect of afferent renal nerve stimulation on blood pressure, heart rate and noradrenergic activity in conscious rats

Kaushik P Patel, M. M. Knuepfer

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The effects of electrical stimulation of afferent renal nerves on arterial pressure, heart rate, and α-methyltyrosine-induced disappearance of norepinephrine in the hypothalamus, contralateral kidney, intestine, and skeletal muscle were studied in conscious rats. There was a significant increase in arterial pressure in response to afferent renal nerve stimulation. There was no significant change in the turnover of norepinephrine in the hypothalamus. However, there was a significant increase in the turnover of norepinephrine in the skeletal muscle, a tendency toward an increase in the intestine, and no change in the contralateral kidney. These results indicate that activation of afferent renal nerve fibers does not change noradrenergic activity in the hypothalamus yet produces a differential sympathetic outflow. Secondly, the increased turnover of norepinephrine in skeletal muscle may be contributing to.

Original languageEnglish (US)
Pages (from-to)121-130
Number of pages10
JournalJournal of the Autonomic Nervous System
Volume17
Issue number2
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Heart Rate
Blood Pressure
Norepinephrine
Kidney
Hypothalamus
Skeletal Muscle
Methyltyrosines
Intestines
Arterial Pressure
Nerve Fibers
Electric Stimulation

Keywords

  • Afferent renal nerve
  • Blood pressure
  • Noradrenergic activity

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology

Cite this

Effect of afferent renal nerve stimulation on blood pressure, heart rate and noradrenergic activity in conscious rats. / Patel, Kaushik P; Knuepfer, M. M.

In: Journal of the Autonomic Nervous System, Vol. 17, No. 2, 01.01.1986, p. 121-130.

Research output: Contribution to journalArticle

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