Effect of a single dose of oral pseudoephedrine on uterine and fetal Doppler blood flow

Carl Vernon Smith, W. F. Rayburn, J. C. Anderson, A. F. Duckworth, L. L. Appel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pseudoephedrine, a stereoisomer of ephedrine with alpha- and beta-adrenergic properties, is the active ingredient in over-the-counter oral decongestants. Its safety during pregnancy has not been studied adequately. The purpose of this investigation was to evaluate the effects of pseudoephedrine on uterine and fetal Doppler blood flows. Twelve healthy pregnant women between 26-40 weeks' gestation ingested a standard 60-mg dose of pseudoephedrine. A pulsed Doppler system was used to perform blood flow measurements of the uterine arcuate artery, fetal aorta, and umbilical artery before dosing, immediately thereafter, and at 15-minute intervals during the first 3 hours after drug ingestion. Blood flow velocities were not altered significantly after dosing in either the maternal or fetal circulation. In no case did absolute fetal or uterine blood flow velocities decrease significantly or systolic/diastolic ratios persistently elevate to abnormal values. We conclude that no significant alterations in the uterine or fetal circulations occur after the ingestion of a single dose of oral pseudoephedrine by healthy pregnant patients in the third trimester.

Original languageEnglish (US)
Pages (from-to)803-806
Number of pages4
JournalObstetrics and gynecology
Volume76
Issue number5 I
DOIs
StatePublished - Jan 1 1990

Fingerprint

Pseudoephedrine
Fetal Blood
Blood Flow Velocity
Eating
Nasal Decongestants
Ephedrine
Uterine Artery
Pregnancy
Umbilical Arteries
Stereoisomerism
Third Pregnancy Trimester
Adrenergic Agents
Aorta
Pregnant Women
Mothers
Safety
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Effect of a single dose of oral pseudoephedrine on uterine and fetal Doppler blood flow. / Smith, Carl Vernon; Rayburn, W. F.; Anderson, J. C.; Duckworth, A. F.; Appel, L. L.

In: Obstetrics and gynecology, Vol. 76, No. 5 I, 01.01.1990, p. 803-806.

Research output: Contribution to journalArticle

Smith, Carl Vernon ; Rayburn, W. F. ; Anderson, J. C. ; Duckworth, A. F. ; Appel, L. L. / Effect of a single dose of oral pseudoephedrine on uterine and fetal Doppler blood flow. In: Obstetrics and gynecology. 1990 ; Vol. 76, No. 5 I. pp. 803-806.
@article{fea5c38d80394ffaabd8b67b1352566e,
title = "Effect of a single dose of oral pseudoephedrine on uterine and fetal Doppler blood flow",
abstract = "Pseudoephedrine, a stereoisomer of ephedrine with alpha- and beta-adrenergic properties, is the active ingredient in over-the-counter oral decongestants. Its safety during pregnancy has not been studied adequately. The purpose of this investigation was to evaluate the effects of pseudoephedrine on uterine and fetal Doppler blood flows. Twelve healthy pregnant women between 26-40 weeks' gestation ingested a standard 60-mg dose of pseudoephedrine. A pulsed Doppler system was used to perform blood flow measurements of the uterine arcuate artery, fetal aorta, and umbilical artery before dosing, immediately thereafter, and at 15-minute intervals during the first 3 hours after drug ingestion. Blood flow velocities were not altered significantly after dosing in either the maternal or fetal circulation. In no case did absolute fetal or uterine blood flow velocities decrease significantly or systolic/diastolic ratios persistently elevate to abnormal values. We conclude that no significant alterations in the uterine or fetal circulations occur after the ingestion of a single dose of oral pseudoephedrine by healthy pregnant patients in the third trimester.",
author = "Smith, {Carl Vernon} and Rayburn, {W. F.} and Anderson, {J. C.} and Duckworth, {A. F.} and Appel, {L. L.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1097/00006250-199011000-00015",
language = "English (US)",
volume = "76",
pages = "803--806",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "5 I",

}

TY - JOUR

T1 - Effect of a single dose of oral pseudoephedrine on uterine and fetal Doppler blood flow

AU - Smith, Carl Vernon

AU - Rayburn, W. F.

AU - Anderson, J. C.

AU - Duckworth, A. F.

AU - Appel, L. L.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Pseudoephedrine, a stereoisomer of ephedrine with alpha- and beta-adrenergic properties, is the active ingredient in over-the-counter oral decongestants. Its safety during pregnancy has not been studied adequately. The purpose of this investigation was to evaluate the effects of pseudoephedrine on uterine and fetal Doppler blood flows. Twelve healthy pregnant women between 26-40 weeks' gestation ingested a standard 60-mg dose of pseudoephedrine. A pulsed Doppler system was used to perform blood flow measurements of the uterine arcuate artery, fetal aorta, and umbilical artery before dosing, immediately thereafter, and at 15-minute intervals during the first 3 hours after drug ingestion. Blood flow velocities were not altered significantly after dosing in either the maternal or fetal circulation. In no case did absolute fetal or uterine blood flow velocities decrease significantly or systolic/diastolic ratios persistently elevate to abnormal values. We conclude that no significant alterations in the uterine or fetal circulations occur after the ingestion of a single dose of oral pseudoephedrine by healthy pregnant patients in the third trimester.

AB - Pseudoephedrine, a stereoisomer of ephedrine with alpha- and beta-adrenergic properties, is the active ingredient in over-the-counter oral decongestants. Its safety during pregnancy has not been studied adequately. The purpose of this investigation was to evaluate the effects of pseudoephedrine on uterine and fetal Doppler blood flows. Twelve healthy pregnant women between 26-40 weeks' gestation ingested a standard 60-mg dose of pseudoephedrine. A pulsed Doppler system was used to perform blood flow measurements of the uterine arcuate artery, fetal aorta, and umbilical artery before dosing, immediately thereafter, and at 15-minute intervals during the first 3 hours after drug ingestion. Blood flow velocities were not altered significantly after dosing in either the maternal or fetal circulation. In no case did absolute fetal or uterine blood flow velocities decrease significantly or systolic/diastolic ratios persistently elevate to abnormal values. We conclude that no significant alterations in the uterine or fetal circulations occur after the ingestion of a single dose of oral pseudoephedrine by healthy pregnant patients in the third trimester.

UR - http://www.scopus.com/inward/record.url?scp=0025188212&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025188212&partnerID=8YFLogxK

U2 - 10.1097/00006250-199011000-00015

DO - 10.1097/00006250-199011000-00015

M3 - Article

C2 - 2216228

AN - SCOPUS:0025188212

VL - 76

SP - 803

EP - 806

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 5 I

ER -