Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation

Felip Pi, Georgina Hotter, Daniel Closa, Joan Roselló-Catafau, Oriol Bulbena, Francesc Badosa, Michael Morris, Laureano Fernández-Cruz, Emilio Gelpí

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Eicosanoid metabolism and its relationship with platelet-activating factor and oxygen free radical production in rat pancreas transplantation has been studied herein. Male Sprague-Dawley rats were classified in 4 experimental groups (n=8 each) as follows: group 1, control; group 2, pancreas transplantation, after 12 hr of organ preservation in University of Wisconsin solution; group 3, same as group 2 with desferrioxamine administration before revascularization of the organ in the recipient rat; and group 4, same as group 3 with administration of a platelet-activating factor antagonist (BN-52021). The results show posttransplantation increases in eicosanoid production in pancreatic tissue. The fact that desferrioxamine and BN-52021 administration could reverse increases in thromboxane B2, leukotriene B4, and 12-hydroxyeicosatetraenoic acid but only BN-52021 affected 6-keto-PGF levels suggests the existence of a close relationship between platelet-activating factor and oxygen free radical in eicosanoid production in pancreas transplantation and it points to a differential role of metabolites produced by circulatory cells and endothelial cells.

Original languageEnglish (US)
Pages (from-to)12-17
Number of pages6
JournalTransplantation
Volume57
Issue number1
StatePublished - Jan 1994

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ginkgolide B
Pancreas Transplantation
Deferoxamine
Eicosanoids
Platelet Activating Factor
Free Radicals
Reactive Oxygen Species
Organ Preservation
Hydroxyeicosatetraenoic Acids
Thromboxane B2
Leukotriene B4
Sprague Dawley Rats
Endothelial Cells
Control Groups

ASJC Scopus subject areas

  • Transplantation

Cite this

Pi, F., Hotter, G., Closa, D., Roselló-Catafau, J., Bulbena, O., Badosa, F., ... Gelpí, E. (1994). Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. Transplantation, 57(1), 12-17.

Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. / Pi, Felip; Hotter, Georgina; Closa, Daniel; Roselló-Catafau, Joan; Bulbena, Oriol; Badosa, Francesc; Morris, Michael; Fernández-Cruz, Laureano; Gelpí, Emilio.

In: Transplantation, Vol. 57, No. 1, 01.1994, p. 12-17.

Research output: Contribution to journalArticle

Pi, F, Hotter, G, Closa, D, Roselló-Catafau, J, Bulbena, O, Badosa, F, Morris, M, Fernández-Cruz, L & Gelpí, E 1994, 'Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation', Transplantation, vol. 57, no. 1, pp. 12-17.
Pi, Felip ; Hotter, Georgina ; Closa, Daniel ; Roselló-Catafau, Joan ; Bulbena, Oriol ; Badosa, Francesc ; Morris, Michael ; Fernández-Cruz, Laureano ; Gelpí, Emilio. / Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. In: Transplantation. 1994 ; Vol. 57, No. 1. pp. 12-17.
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