Effect of a long-acting fluorinated androgen on implantation in 'delayed' mice

Shyamal K Roy, J. SenGupta, S. K. Manchanda

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of fluoxymesterone (FMA), a fluorinated androgen, on ovum implantation has been studied using ovariectomized, progesterone-treated pregnant (delayed) mice. 500 μg FMA, given either continuously from day 4 to 9 or singly on day 8, was able to induce implantation but at the same time caused total resorption of implanted embryos in the case of prolonged treatment with the drug. This anti-estrogenic activity of FMA could be reversed by supplementation of 0.25 μg estradiol-17β given on day 8. Testosterone also induced implantations in 'delayed' mice. FMA and testosterone given to long-term ovariectomized, progesterone-primed mice showed characteristic changes in uterine epithelial cell morphology similar to the attachment found in normal pregnancy. The possible mechanism of action of FMA in early pregnancy will be discussed.

Original languageEnglish (US)
Pages (from-to)22-31
Number of pages10
JournalHormone Research
Volume12
Issue number1
DOIs
StatePublished - Jan 1 1980

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Androgens
Progesterone
Testosterone
Fluoxymesterone
Embryo Loss
Pregnancy
Estradiol
Epithelial Cells
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Effect of a long-acting fluorinated androgen on implantation in 'delayed' mice. / Roy, Shyamal K; SenGupta, J.; Manchanda, S. K.

In: Hormone Research, Vol. 12, No. 1, 01.01.1980, p. 22-31.

Research output: Contribution to journalArticle

Roy, Shyamal K ; SenGupta, J. ; Manchanda, S. K. / Effect of a long-acting fluorinated androgen on implantation in 'delayed' mice. In: Hormone Research. 1980 ; Vol. 12, No. 1. pp. 22-31.
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