Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat

You-Wei Peng, T. Senda, Y. Hao, K. Matsuno, F. Wong

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Rod photoreceptor-specific mutations cause ectopic synapses to form between cone photoreceptor terminals and rod bipolar cell dendrites in degenerating retinas of rhodopsin transgenic (P347L) pigs and retinal degeneration mice. Since the mutations occur in rod photoreceptor-specific genes in these two models, it is not known if ectopic synaptogenesis occurs specifically due to some rod photoreceptor cell-autonomous properties of a mutation or as a general consequence of photoreceptor degeneration. In the Royal College of Surgeons (RCS) rat, a mutation in the receptor tyrosine kinase gene, Mertk, causes failure of the retinal pigment epithelial (RPE) cells to phagocytose shed photoreceptor outer segments; subsequently, both rod and cone photoreceptors die. The non-phagocytic phenotype of the RCS rat is RPE cell-autonomous and the photoreceptors degenerate secondarily. Here we show that in 35-day-old RCS rats, where a majority of rod and cone photoreceptors remained, rod bipolar cell dendrites had abnormal (flat-contact type) synaptic contacts with rod and cone terminals. Demonstration of ectopic synapses in the RCS rat suggested that ectopic synaptogenesis could occur as a result of photoreceptor degeneration, even when the rods and cones were developmentally normal. This further supported the hypothesis that ectopic synaptogenesis may be a common step in the disease progression of different forms of retinal degeneration that include photoreceptor death as a feature, such as retinitis pigmentosa.

Original languageEnglish (US)
Pages (from-to)813-820
Number of pages8
JournalNeuroscience
Volume119
Issue number3
DOIs
StatePublished - Jul 4 2003

Fingerprint

Retinal Rod Photoreceptor Cells
Retinal Degeneration
Vertebrate Photoreceptor Cells
Retinal Cone Photoreceptor Cells
Mutation
Retinal Pigments
Dendrites
Synapses
Epithelial Cells
Cytophagocytosis
Retinitis Pigmentosa
Rhodopsin
Receptor Protein-Tyrosine Kinases
Genes
Disease Progression
Retina
Swine
Surgeons
Phenotype

Keywords

  • Ectopic synaptogenesis
  • Photoreceptor degeneration
  • Retinal degeneration
  • Retinitis pigmentosa
  • Rod bipolar cells
  • Synaptic remodeling

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. / Peng, You-Wei; Senda, T.; Hao, Y.; Matsuno, K.; Wong, F.

In: Neuroscience, Vol. 119, No. 3, 04.07.2003, p. 813-820.

Research output: Contribution to journalArticle

Peng, You-Wei ; Senda, T. ; Hao, Y. ; Matsuno, K. ; Wong, F. / Ectopic synaptogenesis during retinal degeneration in the royal college of surgeons rat. In: Neuroscience. 2003 ; Vol. 119, No. 3. pp. 813-820.
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