Economic analysis off our triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong

J. H S You, K. K C Lee, S. S S Ho, J. J Y Sung, N. N S Kung, M. Yung, C. Lee, Gary C Yee

Research output: Contribution to journalArticle

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Abstract

Background: One-week triple regimens have been shown to be effective for the treatment of Helicobacter pylori-related peptic ulcer disease. Aim: To conduct an economic analysis of four triple regimens for the treatment of H. pylori-related peptic ulcer disease from the perspective of a public health organization in Hong Kong. Methods: Records of 200 patients with H. pylori-related peptic ulcer disease, who had previously participated in a randomized comparison of ranitidine bismuth citrate (RBC) with amoxicillin and clarithromycin (RAC), omeprazole with amoxicillin and clarithromycin (OAC), RBC with metronidazole and tetracycline (RMT), or, colloidal bismuth subcitrate with metronidazole and tetracycline (BMT) in either in-patient or out-patient setting were reviewed. Results: Fifty patients were excluded because of incomplete documentation or lack of peptic ulcer. In the outpatient group (n = 72), the median direct costs of the RAC group (HK $ 5094) were lower those of the BMT (HK $ 5400), RMT (HK $ 5394), or OAC (HK $ 5440) groups, but the difference was significant only between the RAC and BMT groups (P < 0.05). In the in-patient group (n = 78), the median direct costs of the RMT group (HK $ 8524) were significantly lower than those of the OAC (HK $ 13 871) and RAC (HK $ 12 092) groups (P < 0.05), but were similar to those of the BMT group (HK $ 8758). Conclusions: RAC and RMT are the least costly regimens for out-patient and in-patient treatment, respectively, of H. pylori-related peptic ulcer disease in Hong Kong.

Original languageEnglish (US)
Pages (from-to)1009-1015
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume15
Issue number7
DOIs
StatePublished - Jul 7 2001

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Clarithromycin
Amoxicillin
Hong Kong
Peptic Ulcer
Helicobacter pylori
Outpatients
Economics
Metronidazole
Tetracycline
Omeprazole
Therapeutics
Costs and Cost Analysis
Documentation
Public Health
Organizations

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

Economic analysis off our triple regimens for the treatment of Helicobacter pylori-related peptic ulcer disease in in-patient and out-patient settings in Hong Kong. / You, J. H S; Lee, K. K C; Ho, S. S S; Sung, J. J Y; Kung, N. N S; Yung, M.; Lee, C.; Yee, Gary C.

In: Alimentary Pharmacology and Therapeutics, Vol. 15, No. 7, 07.07.2001, p. 1009-1015.

Research output: Contribution to journalArticle

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abstract = "Background: One-week triple regimens have been shown to be effective for the treatment of Helicobacter pylori-related peptic ulcer disease. Aim: To conduct an economic analysis of four triple regimens for the treatment of H. pylori-related peptic ulcer disease from the perspective of a public health organization in Hong Kong. Methods: Records of 200 patients with H. pylori-related peptic ulcer disease, who had previously participated in a randomized comparison of ranitidine bismuth citrate (RBC) with amoxicillin and clarithromycin (RAC), omeprazole with amoxicillin and clarithromycin (OAC), RBC with metronidazole and tetracycline (RMT), or, colloidal bismuth subcitrate with metronidazole and tetracycline (BMT) in either in-patient or out-patient setting were reviewed. Results: Fifty patients were excluded because of incomplete documentation or lack of peptic ulcer. In the outpatient group (n = 72), the median direct costs of the RAC group (HK $ 5094) were lower those of the BMT (HK $ 5400), RMT (HK $ 5394), or OAC (HK $ 5440) groups, but the difference was significant only between the RAC and BMT groups (P < 0.05). In the in-patient group (n = 78), the median direct costs of the RMT group (HK $ 8524) were significantly lower than those of the OAC (HK $ 13 871) and RAC (HK $ 12 092) groups (P < 0.05), but were similar to those of the BMT group (HK $ 8758). Conclusions: RAC and RMT are the least costly regimens for out-patient and in-patient treatment, respectively, of H. pylori-related peptic ulcer disease in Hong Kong.",
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AU - Lee, C.

AU - Yee, Gary C

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