Echovirus 22 is an atypical enterovirus

B. A.G. Coller, Nora M Chapman, M. A. Beck, M. A. Pallansch, C. J. Gauntt, Steven M Tracy

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Although echovirus 22 (EV22) is classified as an enterovirus in the family Picornaviridae, it is atypical of the enterovirus paradigm, typified by the polioviruses and the coxsackie B viruses. cDNA reverse transcribed from coxsackievirus B3 (CVB3) RNA does not hybridize to genomic RNA of EV22, and conversely, cDNA made to EV22 does not hybridize to CVB3 genomic RNA or to molecular clones of CVB3 or poliovirus type 1. EV22 cDNA does not hybridize to viral RNA of encephalomyocarditis virus or to a molecular clone of Theiler's murine encephalomyelitis virus, members of the cardiovirus genus. The genomic RNA of EV22 cannot be detected by the polymerase chain reaction using generic enteroviral primers. EV22 does not shut off host cell protein synthesis, and the RNA of EV22 is efficiently translated in vitro in rabbit reticulocyte lysates. Murine enterovirus-immune T cells recognize and proliferate against EV22 as an antigen in vitro, demonstrating that EV22 shares an epitope(s) common to enteroviruses but not found among other picornaviruses.

Original languageEnglish (US)
Pages (from-to)2692-2701
Number of pages10
JournalJournal of virology
Volume64
Issue number6
StatePublished - Jan 1 1990

Fingerprint

Parechovirus
Enterovirus
RNA
Picornaviridae
Enterovirus C
genomics
Poliovirus
Complementary DNA
Cardiovirus
Theilovirus
Encephalomyocarditis virus
clones
reticulocytes
Clone Cells
Human Enterovirus B
epitopes
RNA Viruses
Reticulocytes
Viral RNA
T-lymphocytes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Coller, B. A. G., Chapman, N. M., Beck, M. A., Pallansch, M. A., Gauntt, C. J., & Tracy, S. M. (1990). Echovirus 22 is an atypical enterovirus. Journal of virology, 64(6), 2692-2701.

Echovirus 22 is an atypical enterovirus. / Coller, B. A.G.; Chapman, Nora M; Beck, M. A.; Pallansch, M. A.; Gauntt, C. J.; Tracy, Steven M.

In: Journal of virology, Vol. 64, No. 6, 01.01.1990, p. 2692-2701.

Research output: Contribution to journalArticle

Coller, BAG, Chapman, NM, Beck, MA, Pallansch, MA, Gauntt, CJ & Tracy, SM 1990, 'Echovirus 22 is an atypical enterovirus', Journal of virology, vol. 64, no. 6, pp. 2692-2701.
Coller BAG, Chapman NM, Beck MA, Pallansch MA, Gauntt CJ, Tracy SM. Echovirus 22 is an atypical enterovirus. Journal of virology. 1990 Jan 1;64(6):2692-2701.
Coller, B. A.G. ; Chapman, Nora M ; Beck, M. A. ; Pallansch, M. A. ; Gauntt, C. J. ; Tracy, Steven M. / Echovirus 22 is an atypical enterovirus. In: Journal of virology. 1990 ; Vol. 64, No. 6. pp. 2692-2701.
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