Eccrine porocarcinoma: New insights and a systematic review of the literature

Azadeh Nazemi, Shauna Higgins, Reyna Swift, Gino In, Kimberly Miller, Ashley Wysong

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

BACKGROUND Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma. RESULTS Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22%). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision. CONCLUSION This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.

Original languageEnglish (US)
Pages (from-to)1247-1261
Number of pages15
JournalDermatologic Surgery
Volume44
Issue number10
DOIs
StatePublished - Jan 1 2018

Fingerprint

Eccrine Porocarcinoma
Mohs Surgery
Skin Neoplasms
Therapeutics
PubMed
Lower Extremity
Neoplasms
Decision Making
Neck
Head
Demography
Guidelines
Neoplasm Metastasis
Morbidity
Mortality

ASJC Scopus subject areas

  • Surgery
  • Dermatology

Cite this

Eccrine porocarcinoma : New insights and a systematic review of the literature. / Nazemi, Azadeh; Higgins, Shauna; Swift, Reyna; In, Gino; Miller, Kimberly; Wysong, Ashley.

In: Dermatologic Surgery, Vol. 44, No. 10, 01.01.2018, p. 1247-1261.

Research output: Contribution to journalReview article

Nazemi, Azadeh ; Higgins, Shauna ; Swift, Reyna ; In, Gino ; Miller, Kimberly ; Wysong, Ashley. / Eccrine porocarcinoma : New insights and a systematic review of the literature. In: Dermatologic Surgery. 2018 ; Vol. 44, No. 10. pp. 1247-1261.
@article{99300fa6e4c243bca98c4392b00866b1,
title = "Eccrine porocarcinoma: New insights and a systematic review of the literature",
abstract = "BACKGROUND Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma. RESULTS Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22{\%}). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision. CONCLUSION This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.",
author = "Azadeh Nazemi and Shauna Higgins and Reyna Swift and Gino In and Kimberly Miller and Ashley Wysong",
year = "2018",
month = "1",
day = "1",
doi = "10.1097/DSS.0000000000001566",
language = "English (US)",
volume = "44",
pages = "1247--1261",
journal = "Dermatologic Surgery",
issn = "1076-0512",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Eccrine porocarcinoma

T2 - New insights and a systematic review of the literature

AU - Nazemi, Azadeh

AU - Higgins, Shauna

AU - Swift, Reyna

AU - In, Gino

AU - Miller, Kimberly

AU - Wysong, Ashley

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma. RESULTS Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22%). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision. CONCLUSION This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.

AB - BACKGROUND Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm with high potential for morbidity and mortality. Due to its rarity, there is a paucity of data profiling diagnosis, work-up, and management. OBJECTIVE To consolidate reported information on demographics, diagnostics, clinical behavior, treatment modalities, and patient outcomes in EPC to provide a reference tool to optimize diagnosis and management. METHODS A comprehensive PubMed search was performed from 1963 to November 2017 using PRISMA guidelines. This yielded 155 articles detailing 206 cases of porocarcinoma. RESULTS Eccrine porocarcinoma most often presents in elderly patients on the head and neck or lower limbs. Metastatic disease at presentation is not uncommon (22%). Primary tumor location is significantly correlated with presence of metastasis (p = .038). The most common treatment is excision followed by Mohs micrographic surgery (MMS), although the outcomes after MMS were superior to those after surgical excision. CONCLUSION This systematic review of individual patient data reveals that all patients should have a histological diagnosis with imaging considered for high-risk cases. Primary tumor location should also be considered in diagnostic and therapeutic decision-making. Although wide local excision (WLE) is currently the first-line treatment, MMS is becoming increasingly used, with evidence indicating improved outcomes as compared to those seen with WLE.

UR - http://www.scopus.com/inward/record.url?scp=85057123465&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057123465&partnerID=8YFLogxK

U2 - 10.1097/DSS.0000000000001566

DO - 10.1097/DSS.0000000000001566

M3 - Review article

C2 - 29894433

AN - SCOPUS:85057123465

VL - 44

SP - 1247

EP - 1261

JO - Dermatologic Surgery

JF - Dermatologic Surgery

SN - 1076-0512

IS - 10

ER -