Early weaning of hiv-exposed uninfected infants and risk of serious gastroenteritis

Findings from two perinatal hiv prevention trials in Kampala, Uganda

Carolyne Onyango-Makumbi, Danstan S Bagenda, Antony Mwatha, Saad B. Omer, Philippa Musoke, Francis Mmiro, Sheryl L. Zwerski, Brenda Asiimwe Kateera, Maria Musisi, Mary Glenn Fowler, J. Brooks Jackson, Laura A. Guay

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

OBJECTIVE: To assess serious gastroenteritis risk and mortality associated with early cessation of breastfeeding in infants enrolled in 2 prevention of maternal-to-child HIV-transmission trials in Uganda. METHODS: We used hazard rates to evaluate serious gastroenteritis events by month of age and mortality among HIV-exposed uninfected infants enrolled in the HIV Network for Prevention Trials (HIVNET 012) (1997-2001) and HIV hyperimmune globulin (HIVIGLOB)/nevirapine (NVP) (2004-2007) trials. HIV-infected mothers were counseled using local infant feeding guidelines current at the time. RESULTS: Breastfeeding cessation occurred earlier in HIVIGLOB/NVP compared with HIVNET 012 (median 4.0 versus 9.3 months, P < 0.001). Rates of serious gastroenteritis were higher in HIVIGLOB/NVP (8.0/1000 child-months) than in HIVNET 012 (3.1/1000 child-months; P < 0.001). Serious gastroenteritis events also peaked earlier at 3-4 and 7-8 months (16.2/1000 and 15.0/1000 child-months, respectively) compared with HIVNET 012 at 9-10 months (20.8/1000 child-months). All cause infant mortality did not statistically differ between the HIVIGLOB/NVP and the HIVNET 012 trials [3.2/1000 versus 2.0/1000 child-months, respectively (P = 0.10)]. CONCLUSIONS: Early breastfeeding cessation seen in the HIVIGLOB/NVP trial was associated with increased risk of serious gastroenteritis among HIV-exposed uninfected infants when compared with later breastfeeding cessation in the HIVNET 012 trial. Testing interventions, which could decrease HIV transmission through breastfeeding and allow safe breastfeeding into the second year of life, are urgently needed.

Original languageEnglish (US)
Pages (from-to)20-27
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2010

Fingerprint

Uganda
Nevirapine
Gastroenteritis
Weaning
Breast Feeding
HIV
Mothers
Mortality
Infant Mortality
HIV hyperimmune globulin
Guidelines

Keywords

  • Breastfeeding cessation
  • HIV
  • Infants
  • Mortality
  • Serious gastroenteritis
  • Uganda

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Early weaning of hiv-exposed uninfected infants and risk of serious gastroenteritis : Findings from two perinatal hiv prevention trials in Kampala, Uganda. / Onyango-Makumbi, Carolyne; Bagenda, Danstan S; Mwatha, Antony; Omer, Saad B.; Musoke, Philippa; Mmiro, Francis; Zwerski, Sheryl L.; Asiimwe Kateera, Brenda; Musisi, Maria; Fowler, Mary Glenn; Jackson, J. Brooks; Guay, Laura A.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 53, No. 1, 01.01.2010, p. 20-27.

Research output: Contribution to journalArticle

Onyango-Makumbi, C, Bagenda, DS, Mwatha, A, Omer, SB, Musoke, P, Mmiro, F, Zwerski, SL, Asiimwe Kateera, B, Musisi, M, Fowler, MG, Jackson, JB & Guay, LA 2010, 'Early weaning of hiv-exposed uninfected infants and risk of serious gastroenteritis: Findings from two perinatal hiv prevention trials in Kampala, Uganda', Journal of Acquired Immune Deficiency Syndromes, vol. 53, no. 1, pp. 20-27. https://doi.org/10.1097/QAI.0b013e3181bdf68e
Onyango-Makumbi, Carolyne ; Bagenda, Danstan S ; Mwatha, Antony ; Omer, Saad B. ; Musoke, Philippa ; Mmiro, Francis ; Zwerski, Sheryl L. ; Asiimwe Kateera, Brenda ; Musisi, Maria ; Fowler, Mary Glenn ; Jackson, J. Brooks ; Guay, Laura A. / Early weaning of hiv-exposed uninfected infants and risk of serious gastroenteritis : Findings from two perinatal hiv prevention trials in Kampala, Uganda. In: Journal of Acquired Immune Deficiency Syndromes. 2010 ; Vol. 53, No. 1. pp. 20-27.
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abstract = "OBJECTIVE: To assess serious gastroenteritis risk and mortality associated with early cessation of breastfeeding in infants enrolled in 2 prevention of maternal-to-child HIV-transmission trials in Uganda. METHODS: We used hazard rates to evaluate serious gastroenteritis events by month of age and mortality among HIV-exposed uninfected infants enrolled in the HIV Network for Prevention Trials (HIVNET 012) (1997-2001) and HIV hyperimmune globulin (HIVIGLOB)/nevirapine (NVP) (2004-2007) trials. HIV-infected mothers were counseled using local infant feeding guidelines current at the time. RESULTS: Breastfeeding cessation occurred earlier in HIVIGLOB/NVP compared with HIVNET 012 (median 4.0 versus 9.3 months, P < 0.001). Rates of serious gastroenteritis were higher in HIVIGLOB/NVP (8.0/1000 child-months) than in HIVNET 012 (3.1/1000 child-months; P < 0.001). Serious gastroenteritis events also peaked earlier at 3-4 and 7-8 months (16.2/1000 and 15.0/1000 child-months, respectively) compared with HIVNET 012 at 9-10 months (20.8/1000 child-months). All cause infant mortality did not statistically differ between the HIVIGLOB/NVP and the HIVNET 012 trials [3.2/1000 versus 2.0/1000 child-months, respectively (P = 0.10)]. CONCLUSIONS: Early breastfeeding cessation seen in the HIVIGLOB/NVP trial was associated with increased risk of serious gastroenteritis among HIV-exposed uninfected infants when compared with later breastfeeding cessation in the HIVNET 012 trial. Testing interventions, which could decrease HIV transmission through breastfeeding and allow safe breastfeeding into the second year of life, are urgently needed.",
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