Early changes in islet hormone secretion in the hamster pancreatic cancer model

Apollina Goel, Surinder Kumar Batra

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The diabetic state that is seen at a high frequency in association with pancreatic cancer is characterized by elevated plasma levels of several islet hormones and by marked insulin resistance. Both the diabetic state and insulin sensitivity improve after tumor removal by sub-total pancreatectomy. Impaired glucose tolerance has also been found in the hamster pancreatic cancer model, but conflicting data regarding islet function have been reported. In order to further investigate islet function and secretion during early development of pancreatic cancer, we measured the concentrations of insulin, glucagon, somatostatin, and islet amyloid polypeptide (IAPP) in plasma, pancreatic tissue and secretin-stimulated pancreatic juice at 12 and 27 weeks after the ductal-cell-specific carcinogen, BOP had been used to induce tumors in Syrian golden hamsters. At 12 weeks after BOP, plasma glucagon levels were significantly increased. An exaggerated plasma-glucose response and concomitant hyperinsulinemia were observed at 27 but not 12 weeks after BOP. Plasma IAPP concentrations, but not glucagon or somatostatin, were elevated at 27 weeks. Tissue concentrations of IAPP were substantially reduced in BOP-treated hamsters at 27 weeks. No differences in hormone concentrations were seen in pancreatic juice from the two groups at either of the two time points investigated. The study showed that islet hormone changes accompany the early development of pancreatic tumors in the hamster pancreatic model. The hormone changes and apparent insulin resistance resemble the metabolic changes found in humans with pancreatic cancer. Teratogenesis Carcinog. Mutagen.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalTeratogenesis Carcinogenesis and Mutagenesis
Volume21
Issue number1
DOIs
StatePublished - Jan 30 2001

Fingerprint

Pancreatic Neoplasms
Cricetinae
Islet Amyloid Polypeptide
Hormones
Plasmas
Glucagon
Insulin
Insulin Resistance
Pancreatic Juice
Tumors
Somatostatin
Tissue
Teratogenesis
Glucose
Neoplasms
Pancreatectomy
Secretin
Glucose Intolerance
Mesocricetus
Mutagens

Keywords

  • Diabetes
  • Hamster
  • IAPP
  • Insulin resistance
  • Islet amyloid polypeptide
  • Pancreatic cancer

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Toxicology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis

Cite this

Early changes in islet hormone secretion in the hamster pancreatic cancer model. / Goel, Apollina; Batra, Surinder Kumar.

In: Teratogenesis Carcinogenesis and Mutagenesis, Vol. 21, No. 1, 30.01.2001, p. 59-67.

Research output: Contribution to journalArticle

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