Early adaptation of human lower extremity vein grafts: Wall stiffness changes accompany geometric remodeling

Jeffrey G. Jacot, Ibrahim Abdullah, Michael Belkin, Marie Gerhard-Herman, Peter Gaccione, Joseph F. Polak, Magruder C. Donaldson, Anthony D. Whittemore, Michael S. Conte

Research output: Contribution to journalArticle

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Abstract

Objective: To quantitatively describe the temporal changes in elastic properties and wall dimensions in lower-extremity vein grafts after implantation. Design of study: This is a prospective study of patients (N = 38) undergoing lower extremity bypass grafts (N = 41) with autologous veins. Pulse wave velocity (PWV), luminal diameter, and wall thickness measurements were obtained by duplex ultrasound scan intraoperatively and at 1, 3, and 6 months postoperatively for assessment of graft dimensions and wall stiffness. Results: Lower extremity vein grafts showed an increase in PWV (from 16 ± 1 to 21 ± 3 cm/s; mean ± SEM; P = .08), reflecting an increase in wall stiffness (from 1.2 ± 0.2 to 2.5 ± 0.7 × 106 dynes/cm; P = .02) and wall thickness (from 0.47 ± 0.03 to 0.61 ± 0.004 mm; P = .04) over the first 6 months after implantation. Changes in lumen diameter were positively correlated with changes in external graft diameter (P < .01) and negatively correlated with initial lumen diameter (P < .01) but not with changes in the wall thickness. Conclusions: These results suggest complex remodeling of vein grafts during the first several months after implantation, with increased wall thickness occurring independent of variable changes in lumen diameter. Simultaneously, a marked increase in wall stiffness over this interval suggests a likely role for collagen deposition.

Original languageEnglish (US)
Pages (from-to)547-555
Number of pages9
JournalJournal of vascular surgery
Volume39
Issue number3
DOIs
StatePublished - Mar 2004

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Lower Extremity
Veins
Transplants
Pulse Wave Analysis
Collagen
Prospective Studies

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Jacot, J. G., Abdullah, I., Belkin, M., Gerhard-Herman, M., Gaccione, P., Polak, J. F., ... Conte, M. S. (2004). Early adaptation of human lower extremity vein grafts: Wall stiffness changes accompany geometric remodeling. Journal of vascular surgery, 39(3), 547-555. https://doi.org/10.1016/j.jvs.2003.09.045

Early adaptation of human lower extremity vein grafts : Wall stiffness changes accompany geometric remodeling. / Jacot, Jeffrey G.; Abdullah, Ibrahim; Belkin, Michael; Gerhard-Herman, Marie; Gaccione, Peter; Polak, Joseph F.; Donaldson, Magruder C.; Whittemore, Anthony D.; Conte, Michael S.

In: Journal of vascular surgery, Vol. 39, No. 3, 03.2004, p. 547-555.

Research output: Contribution to journalArticle

Jacot, JG, Abdullah, I, Belkin, M, Gerhard-Herman, M, Gaccione, P, Polak, JF, Donaldson, MC, Whittemore, AD & Conte, MS 2004, 'Early adaptation of human lower extremity vein grafts: Wall stiffness changes accompany geometric remodeling', Journal of vascular surgery, vol. 39, no. 3, pp. 547-555. https://doi.org/10.1016/j.jvs.2003.09.045
Jacot, Jeffrey G. ; Abdullah, Ibrahim ; Belkin, Michael ; Gerhard-Herman, Marie ; Gaccione, Peter ; Polak, Joseph F. ; Donaldson, Magruder C. ; Whittemore, Anthony D. ; Conte, Michael S. / Early adaptation of human lower extremity vein grafts : Wall stiffness changes accompany geometric remodeling. In: Journal of vascular surgery. 2004 ; Vol. 39, No. 3. pp. 547-555.
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