E-cadherin mediates adherens junction organization through protein kinase C

J. E. Lewis, P. J. Jensen, Keith R Johnson, M. J. Wheelock

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Cultured human keratinocytes maintained in 30 μM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.

Original languageEnglish (US)
Pages (from-to)3615-3621
Number of pages7
JournalJournal of Cell Science
Volume107
Issue number12
StatePublished - Dec 1 1994

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Adherens Junctions
Cadherins
Protein Kinase C
Keratinocytes

Keywords

  • Cadherin
  • Keratinocyte
  • Protein kinase C

ASJC Scopus subject areas

  • Cell Biology

Cite this

Lewis, J. E., Jensen, P. J., Johnson, K. R., & Wheelock, M. J. (1994). E-cadherin mediates adherens junction organization through protein kinase C. Journal of Cell Science, 107(12), 3615-3621.

E-cadherin mediates adherens junction organization through protein kinase C. / Lewis, J. E.; Jensen, P. J.; Johnson, Keith R; Wheelock, M. J.

In: Journal of Cell Science, Vol. 107, No. 12, 01.12.1994, p. 3615-3621.

Research output: Contribution to journalArticle

Lewis, JE, Jensen, PJ, Johnson, KR & Wheelock, MJ 1994, 'E-cadherin mediates adherens junction organization through protein kinase C', Journal of Cell Science, vol. 107, no. 12, pp. 3615-3621.
Lewis, J. E. ; Jensen, P. J. ; Johnson, Keith R ; Wheelock, M. J. / E-cadherin mediates adherens junction organization through protein kinase C. In: Journal of Cell Science. 1994 ; Vol. 107, No. 12. pp. 3615-3621.
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