Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: Comparison of Gd-DTPA and NMS60

Yutong Liu, Helen D'Arceuil, Julian He, Mike Duggan, S. Seri, Yuji Hashiguchi, Akira Nakatani, R. Gilberto Gonzalez, Johnny Pryor, Alex De Crespigny

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Abstract

Purpose: To study a new gadolinium (Gd) contrast agent-NMS60-for MR perfusion-weighted Imaging (PWI) of brain tissue. Materials and Methods: NMS60 is a Gd3+ trimer with a molecular weight of 2158 Daltons, and a T2 relaxivity almost three times higher than that of Gd-DTPA. Middle cerebral artery (MCA) occlusion was induced in nine nonhuman primates. The animals were scanned acutely and for up to six follow-up time points. PWI peak, and time-to-peak maps were generated, and perfusion deficit volumes were measured from these maps. The values of peak, time-to-peak, and perfusion deficit volume were compared between NMS60 and GD-DTPA Results: These results demonstrate that there was no significant difference in our calculated perfusion parameters between the two contrast agents. Conclusion: The two agents were found to be equally effective for PWI for acute and chronic stroke in primates. Along with its previously demonstrated advantage for T1-enhanced imaging, the current results show that NMS60 is a viable contrast agent for use in stroke patients.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume22
Issue number4
DOIs
StatePublished - Oct 1 2005

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Keywords

  • Cerebral ischemia
  • Gadolinium
  • MRI contrast media
  • Perfusion-weighted imaging
  • Stroke

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Liu, Y., D'Arceuil, H., He, J., Duggan, M., Seri, S., Hashiguchi, Y., Nakatani, A., Gonzalez, R. G., Pryor, J., & De Crespigny, A. (2005). Dynamic susceptibility contrast perfusion imaging of cerebral ischemia in nonhuman primates: Comparison of Gd-DTPA and NMS60. Journal of Magnetic Resonance Imaging, 22(4), 461-466. https://doi.org/10.1002/jmri.20403