Duration and biological half-life of passively acquired colostral antibodies to porcine parvovirus.

Prem S Paul, W. L. Mengeling, E. C. Pirtle

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The duration of passive immunity and biological half-lives of passively acquired antibodies to porcine parvovirus (PPV) were determined in 4 pigs from each of 10 litters. All sows were randomly selected from a herd naturally infected with PPV. At parturition, blood and colostral samples from the 10 sows contained hemagglutination-inhibiting (HI) antibodies to PPV; the HI titers of colostrum were about 5 times higher than that of serum. The HI antibodies in serum and colostrum of sows were resistant to 2-mercaptoethanol, indicating that antibodies were of immunoglobulin G class. Pigs were allowed to suckle, and their blood samples were collected at 2 days of age and every 2 weeks thereafter. At 3 to 4 weeks of age, pigs were weaned and moved to an isolation facility. All pigs had HI antibodies to PPV at 2 days of age. Passively acquired antibodies steadily decreased from the circulation of pigs, and the rate of antibody decrease was similar in all pigs. Antibodies to PPV persisted for about 16 to 24 (mean 21.2) weeks, and all pigs were seronegative at 26 weeks of age. Pigs were susceptible to experimental infection with PPV as early as 1 week after they became seronegative. The biological half-lives of antibodies to PPV, unadjusted and adjusted for body weight gain, were determined to be approximately 19.7 and 29.0 days, respectively.

Original languageEnglish (US)
Pages (from-to)1376-1379
Number of pages4
JournalAmerican journal of veterinary research
Volume43
Issue number8
StatePublished - Aug 1 1982

Fingerprint

Porcine Parvovirus
Ungulate protoparvovirus 1
biological half-life
Half-Life
Swine
antibodies
duration
Antibodies
swine
Hemagglutination
hemagglutination
sows
Colostrum
blood serum
colostrum
passive immunity
Mercaptoethanol
Immunoglobulin Isotypes
immunoglobulin G
blood

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Duration and biological half-life of passively acquired colostral antibodies to porcine parvovirus. / Paul, Prem S; Mengeling, W. L.; Pirtle, E. C.

In: American journal of veterinary research, Vol. 43, No. 8, 01.08.1982, p. 1376-1379.

Research output: Contribution to journalArticle

Paul, Prem S ; Mengeling, W. L. ; Pirtle, E. C. / Duration and biological half-life of passively acquired colostral antibodies to porcine parvovirus. In: American journal of veterinary research. 1982 ; Vol. 43, No. 8. pp. 1376-1379.
@article{6c98be5943ba4d32a4b5d28e22a0d7f9,
title = "Duration and biological half-life of passively acquired colostral antibodies to porcine parvovirus.",
abstract = "The duration of passive immunity and biological half-lives of passively acquired antibodies to porcine parvovirus (PPV) were determined in 4 pigs from each of 10 litters. All sows were randomly selected from a herd naturally infected with PPV. At parturition, blood and colostral samples from the 10 sows contained hemagglutination-inhibiting (HI) antibodies to PPV; the HI titers of colostrum were about 5 times higher than that of serum. The HI antibodies in serum and colostrum of sows were resistant to 2-mercaptoethanol, indicating that antibodies were of immunoglobulin G class. Pigs were allowed to suckle, and their blood samples were collected at 2 days of age and every 2 weeks thereafter. At 3 to 4 weeks of age, pigs were weaned and moved to an isolation facility. All pigs had HI antibodies to PPV at 2 days of age. Passively acquired antibodies steadily decreased from the circulation of pigs, and the rate of antibody decrease was similar in all pigs. Antibodies to PPV persisted for about 16 to 24 (mean 21.2) weeks, and all pigs were seronegative at 26 weeks of age. Pigs were susceptible to experimental infection with PPV as early as 1 week after they became seronegative. The biological half-lives of antibodies to PPV, unadjusted and adjusted for body weight gain, were determined to be approximately 19.7 and 29.0 days, respectively.",
author = "Paul, {Prem S} and Mengeling, {W. L.} and Pirtle, {E. C.}",
year = "1982",
month = "8",
day = "1",
language = "English (US)",
volume = "43",
pages = "1376--1379",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "8",

}

TY - JOUR

T1 - Duration and biological half-life of passively acquired colostral antibodies to porcine parvovirus.

AU - Paul, Prem S

AU - Mengeling, W. L.

AU - Pirtle, E. C.

PY - 1982/8/1

Y1 - 1982/8/1

N2 - The duration of passive immunity and biological half-lives of passively acquired antibodies to porcine parvovirus (PPV) were determined in 4 pigs from each of 10 litters. All sows were randomly selected from a herd naturally infected with PPV. At parturition, blood and colostral samples from the 10 sows contained hemagglutination-inhibiting (HI) antibodies to PPV; the HI titers of colostrum were about 5 times higher than that of serum. The HI antibodies in serum and colostrum of sows were resistant to 2-mercaptoethanol, indicating that antibodies were of immunoglobulin G class. Pigs were allowed to suckle, and their blood samples were collected at 2 days of age and every 2 weeks thereafter. At 3 to 4 weeks of age, pigs were weaned and moved to an isolation facility. All pigs had HI antibodies to PPV at 2 days of age. Passively acquired antibodies steadily decreased from the circulation of pigs, and the rate of antibody decrease was similar in all pigs. Antibodies to PPV persisted for about 16 to 24 (mean 21.2) weeks, and all pigs were seronegative at 26 weeks of age. Pigs were susceptible to experimental infection with PPV as early as 1 week after they became seronegative. The biological half-lives of antibodies to PPV, unadjusted and adjusted for body weight gain, were determined to be approximately 19.7 and 29.0 days, respectively.

AB - The duration of passive immunity and biological half-lives of passively acquired antibodies to porcine parvovirus (PPV) were determined in 4 pigs from each of 10 litters. All sows were randomly selected from a herd naturally infected with PPV. At parturition, blood and colostral samples from the 10 sows contained hemagglutination-inhibiting (HI) antibodies to PPV; the HI titers of colostrum were about 5 times higher than that of serum. The HI antibodies in serum and colostrum of sows were resistant to 2-mercaptoethanol, indicating that antibodies were of immunoglobulin G class. Pigs were allowed to suckle, and their blood samples were collected at 2 days of age and every 2 weeks thereafter. At 3 to 4 weeks of age, pigs were weaned and moved to an isolation facility. All pigs had HI antibodies to PPV at 2 days of age. Passively acquired antibodies steadily decreased from the circulation of pigs, and the rate of antibody decrease was similar in all pigs. Antibodies to PPV persisted for about 16 to 24 (mean 21.2) weeks, and all pigs were seronegative at 26 weeks of age. Pigs were susceptible to experimental infection with PPV as early as 1 week after they became seronegative. The biological half-lives of antibodies to PPV, unadjusted and adjusted for body weight gain, were determined to be approximately 19.7 and 29.0 days, respectively.

UR - http://www.scopus.com/inward/record.url?scp=0020174059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020174059&partnerID=8YFLogxK

M3 - Article

VL - 43

SP - 1376

EP - 1379

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 8

ER -