Dual neurocircuitry dysfunctions in disruptive behavior disorders: Emotional responding and response inhibition

Soonjo Hwang, Z. T. Nolan, Stuart F White, W. C. Williams, S. Sinclair, Robert James Blair

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Background To determine the functional integrity of the neural systems involved in emotional responding/regulation and response control/inhibition in youth (age 10-18 years) with disruptive behavioral disorders (DBDs: conduct disorder and/or oppositional defiant disorder) as a function of callous-unemotional (CU) traits. Method Twenty-eight healthy youths and 35 youths with DBD [high CU (HCU), n = 18; low CU (LCU), n = 17] performed the fMRI Affective Stroop task. Participants viewed positive, neutral, and negative images under varying levels of cognitive load. A 3-way ANOVA (group×emotion by task) was conducted on the BOLD response data. Results Youth with DBD-HCU showed significantly less activation of ventromedial prefrontal cortex (vmPFC) and amygdala in response to negative stimuli, compared to healthy youth and youth with DBD-LCU. vmPFC responsiveness was inversely related to CU symptoms in DBD. Youth with DBD-LCU showed decreased functional connectivity between amygdala and regions including inferior frontal gyrus in response to emotional stimuli. Youth with DBD (LCU and HCU) additionally showed decreased insula responsiveness to high load (incongruent trials) compared to healthy youth. Insula responsiveness was inversely related to ADHD symptoms in DBD. Conclusions These data reveal two forms of pathophysiology in DBD. One associated with reduced amygdala and vmPFC responses to negative stimuli and related to increased CU traits. Another associated with reduced insula responses during high load task trials and related to ADHD symptoms. Appropriate treatment will need to be individualized according to the patient's specific pathophysiology.

Original languageEnglish (US)
Pages (from-to)1485-1496
Number of pages12
JournalPsychological medicine
Volume46
Issue number7
DOIs
StatePublished - May 1 2016

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Attention Deficit and Disruptive Behavior Disorders
Prefrontal Cortex
Amygdala
Inhibition (Psychology)
Conduct Disorder
Analysis of Variance
Magnetic Resonance Imaging

Keywords

  • Amygdala
  • callous-unemotional trait
  • disruptive behavior disorder
  • emotional responding
  • response inhibition

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

Cite this

Dual neurocircuitry dysfunctions in disruptive behavior disorders : Emotional responding and response inhibition. / Hwang, Soonjo; Nolan, Z. T.; White, Stuart F; Williams, W. C.; Sinclair, S.; Blair, Robert James.

In: Psychological medicine, Vol. 46, No. 7, 01.05.2016, p. 1485-1496.

Research output: Contribution to journalArticle

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abstract = "Background To determine the functional integrity of the neural systems involved in emotional responding/regulation and response control/inhibition in youth (age 10-18 years) with disruptive behavioral disorders (DBDs: conduct disorder and/or oppositional defiant disorder) as a function of callous-unemotional (CU) traits. Method Twenty-eight healthy youths and 35 youths with DBD [high CU (HCU), n = 18; low CU (LCU), n = 17] performed the fMRI Affective Stroop task. Participants viewed positive, neutral, and negative images under varying levels of cognitive load. A 3-way ANOVA (group×emotion by task) was conducted on the BOLD response data. Results Youth with DBD-HCU showed significantly less activation of ventromedial prefrontal cortex (vmPFC) and amygdala in response to negative stimuli, compared to healthy youth and youth with DBD-LCU. vmPFC responsiveness was inversely related to CU symptoms in DBD. Youth with DBD-LCU showed decreased functional connectivity between amygdala and regions including inferior frontal gyrus in response to emotional stimuli. Youth with DBD (LCU and HCU) additionally showed decreased insula responsiveness to high load (incongruent trials) compared to healthy youth. Insula responsiveness was inversely related to ADHD symptoms in DBD. Conclusions These data reveal two forms of pathophysiology in DBD. One associated with reduced amygdala and vmPFC responses to negative stimuli and related to increased CU traits. Another associated with reduced insula responses during high load task trials and related to ADHD symptoms. Appropriate treatment will need to be individualized according to the patient's specific pathophysiology.",
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