Dual-function CXCR4 antagonist polyplexes to deliver gene therapy and inhibit cancer cell invasion

Jing Li, Yu Zhu, Stuart T. Hazeldine, Chunying Li, David Oupický

Research output: Contribution to journalArticle

53 Scopus citations


Giving a one-two punch: A bicyclam-based biodegradable polycation with CXCR4 antagonistic activity shows potential for combining cancer chemotherapy with gene therapy or siRNA therapy. This dual-function polycation prevents cancer cell invasion by inhibiting CXCL12-stimulated CXCR4 activation (see scheme), while at the same time efficiently and safely delivering therapeutic DNA into cancer cells.

Original languageEnglish (US)
Pages (from-to)8740-8743
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number35
StatePublished - Aug 27 2012



  • CXCR4
  • DNA
  • drug delivery
  • polyplexes
  • transfection

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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