Dual activation of the inositol-triphosphate-calcium and cyclic nucleotide intracellular signaling systems by adrenocorticotropin in rat adrenal cells

Robert V. Farese, Nenad Rosic, Jeffrey Babischkin, Margaret G. Farese, Richard Foster, John S. Davis

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Hormones which primarily utilize cAMP as their intracellular "second messenger" are generally not thought to activate the IP3-Ca++ signalling system. Presently, we show that ACTH, at certain concentrations, can activate both the cAMP and IP3-Ca++ intracellular signalling systems.

Original languageEnglish (US)
Pages (from-to)742-748
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume135
Issue number3
DOIs
StatePublished - Mar 28 1986

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Cyclic Nucleotides
Second Messenger Systems
Inositol
Adrenocorticotropic Hormone
Rats
Chemical activation
Hormones
Calcium
triphosphoric acid

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Dual activation of the inositol-triphosphate-calcium and cyclic nucleotide intracellular signaling systems by adrenocorticotropin in rat adrenal cells. / Farese, Robert V.; Rosic, Nenad; Babischkin, Jeffrey; Farese, Margaret G.; Foster, Richard; Davis, John S.

In: Biochemical and Biophysical Research Communications, Vol. 135, No. 3, 28.03.1986, p. 742-748.

Research output: Contribution to journalArticle

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