Drug-Induced Paradoxical Vocal Fold Motion

Marlene Garcia-Neuer, Donna Marie Lynch, Kathleen Marquis, Jayme Dowdall, Mariana Castells, David Edward Sloane

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Vocal cord dysfunction, also known as paradoxical vocal fold motion (PVFM), is a disorder characterized by abnormal vocal cord adduction during inspiration. PVFM is commonly misdiagnosed as asthma because of the similarity of symptoms: cough, wheezing, chest pain, and dyspnea. We present the clinical vignette of a 36-year-old woman with juvenile rheumatoid arthritis and multiple adverse drug reactions who presented with recurrent episodes of unrecognized PVFM during skin testing for drug allergy, omalizumab treatment, and tocilizumab desensitization. Before the diagnosis of PVFM, these episodes were treated as anaphylaxis, including the administration of epinephrine. Once diagnosed and treated for PVFM, the patient did not present any further events and continued treatment for drug allergy. PVFM may be underreported in hypersensitivity reactions because of the similarity to Type 1-mediated respiratory symptoms and comorbid asthma.

Original languageEnglish (US)
Pages (from-to)90-94
Number of pages5
JournalJournal of Allergy and Clinical Immunology: In Practice
Volume6
Issue number1
DOIs
StatePublished - Jan 2018

Fingerprint

Vocal Cord Dysfunction
Pharmaceutical Preparations
Drug Hypersensitivity
Asthma
Juvenile Arthritis
Vocal Cords
Respiratory Sounds
Anaphylaxis
Diagnostic Errors
Drug-Related Side Effects and Adverse Reactions
Chest Pain
Cough
Dyspnea
Epinephrine
Hypersensitivity
Skin

Keywords

  • Adverse drug reaction
  • Anaphylaxis
  • Desensitization
  • Drug hypersensitivity
  • Paradoxical vocal fold motion
  • Vocal cord dysfunction

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Drug-Induced Paradoxical Vocal Fold Motion. / Garcia-Neuer, Marlene; Lynch, Donna Marie; Marquis, Kathleen; Dowdall, Jayme; Castells, Mariana; Sloane, David Edward.

In: Journal of Allergy and Clinical Immunology: In Practice, Vol. 6, No. 1, 01.2018, p. 90-94.

Research output: Contribution to journalArticle

Garcia-Neuer, M, Lynch, DM, Marquis, K, Dowdall, J, Castells, M & Sloane, DE 2018, 'Drug-Induced Paradoxical Vocal Fold Motion', Journal of Allergy and Clinical Immunology: In Practice, vol. 6, no. 1, pp. 90-94. https://doi.org/10.1016/j.jaip.2017.08.020
Garcia-Neuer, Marlene ; Lynch, Donna Marie ; Marquis, Kathleen ; Dowdall, Jayme ; Castells, Mariana ; Sloane, David Edward. / Drug-Induced Paradoxical Vocal Fold Motion. In: Journal of Allergy and Clinical Immunology: In Practice. 2018 ; Vol. 6, No. 1. pp. 90-94.
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