Drosophila melanogaster as a complementary system for studying HIV-1-related genes and proteins

Cole R. Spresser, Kim A Carlson

Research output: Contribution to journalShort survey

5 Citations (Scopus)

Abstract

Human immunodeficiency virus type 1 (HIV-1) persists as a pandemic even though new information about the virus is being discovered on a daily basis. If the brain becomes infected, HIV-1 encephalitis or HIV-1-associated dementia may develop. There is much to be learned about the modes of action and mechanisms of genes and proteins, and their interactions that underlie HIV-1 infection. Drosophila melanogaster has been used successfully to study genes and proteins related to HIV-1 infection, including but not limited to the disturbance of antimicrobial responses by viral protein U and the identification of D. melanogaster analogs to the serine palmitoyltransferase 5 and 6 proteins that play a role in activation of transcription by the HIV-1 Tat protein in human cells. We believe that utilizing D. melanogaster as a complementary system for the study of genes and proteins related to HIV-1 infection will provide useful information that will lead to new studies designed to enhance our understanding of the mechanistic roles of these molecules. In the present study, we focus on the utilization of D. melanogaster as a complementary system for studying HIV-1 related genes and proteins, why this research should be extended, and why this complementary system is an important method for enhancing our understanding of the genetics involved in HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
JournalJournal of Neuroscience Research
Volume80
Issue number4
DOIs
StatePublished - May 15 2005

Fingerprint

Drosophila melanogaster
HIV-1
Virus Diseases
Proteins
Serine C-Palmitoyltransferase
tat Gene Products
Viral Proteins
Pandemics
Encephalitis
Transcriptional Activation
Dementia
Viruses
Brain
Research

Keywords

  • Analogous proteins
  • Complementary system
  • Transgenic lines

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Drosophila melanogaster as a complementary system for studying HIV-1-related genes and proteins. / Spresser, Cole R.; Carlson, Kim A.

In: Journal of Neuroscience Research, Vol. 80, No. 4, 15.05.2005, p. 451-455.

Research output: Contribution to journalShort survey

@article{f770ea1fa82c42b58bfc1f7997dfd8e9,
title = "Drosophila melanogaster as a complementary system for studying HIV-1-related genes and proteins",
abstract = "Human immunodeficiency virus type 1 (HIV-1) persists as a pandemic even though new information about the virus is being discovered on a daily basis. If the brain becomes infected, HIV-1 encephalitis or HIV-1-associated dementia may develop. There is much to be learned about the modes of action and mechanisms of genes and proteins, and their interactions that underlie HIV-1 infection. Drosophila melanogaster has been used successfully to study genes and proteins related to HIV-1 infection, including but not limited to the disturbance of antimicrobial responses by viral protein U and the identification of D. melanogaster analogs to the serine palmitoyltransferase 5 and 6 proteins that play a role in activation of transcription by the HIV-1 Tat protein in human cells. We believe that utilizing D. melanogaster as a complementary system for the study of genes and proteins related to HIV-1 infection will provide useful information that will lead to new studies designed to enhance our understanding of the mechanistic roles of these molecules. In the present study, we focus on the utilization of D. melanogaster as a complementary system for studying HIV-1 related genes and proteins, why this research should be extended, and why this complementary system is an important method for enhancing our understanding of the genetics involved in HIV-1 infection.",
keywords = "Analogous proteins, Complementary system, Transgenic lines",
author = "Spresser, {Cole R.} and Carlson, {Kim A}",
year = "2005",
month = "5",
day = "15",
doi = "10.1002/jnr.20460",
language = "English (US)",
volume = "80",
pages = "451--455",
journal = "Journal of Neuroscience Research",
issn = "0360-4012",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Drosophila melanogaster as a complementary system for studying HIV-1-related genes and proteins

AU - Spresser, Cole R.

AU - Carlson, Kim A

PY - 2005/5/15

Y1 - 2005/5/15

N2 - Human immunodeficiency virus type 1 (HIV-1) persists as a pandemic even though new information about the virus is being discovered on a daily basis. If the brain becomes infected, HIV-1 encephalitis or HIV-1-associated dementia may develop. There is much to be learned about the modes of action and mechanisms of genes and proteins, and their interactions that underlie HIV-1 infection. Drosophila melanogaster has been used successfully to study genes and proteins related to HIV-1 infection, including but not limited to the disturbance of antimicrobial responses by viral protein U and the identification of D. melanogaster analogs to the serine palmitoyltransferase 5 and 6 proteins that play a role in activation of transcription by the HIV-1 Tat protein in human cells. We believe that utilizing D. melanogaster as a complementary system for the study of genes and proteins related to HIV-1 infection will provide useful information that will lead to new studies designed to enhance our understanding of the mechanistic roles of these molecules. In the present study, we focus on the utilization of D. melanogaster as a complementary system for studying HIV-1 related genes and proteins, why this research should be extended, and why this complementary system is an important method for enhancing our understanding of the genetics involved in HIV-1 infection.

AB - Human immunodeficiency virus type 1 (HIV-1) persists as a pandemic even though new information about the virus is being discovered on a daily basis. If the brain becomes infected, HIV-1 encephalitis or HIV-1-associated dementia may develop. There is much to be learned about the modes of action and mechanisms of genes and proteins, and their interactions that underlie HIV-1 infection. Drosophila melanogaster has been used successfully to study genes and proteins related to HIV-1 infection, including but not limited to the disturbance of antimicrobial responses by viral protein U and the identification of D. melanogaster analogs to the serine palmitoyltransferase 5 and 6 proteins that play a role in activation of transcription by the HIV-1 Tat protein in human cells. We believe that utilizing D. melanogaster as a complementary system for the study of genes and proteins related to HIV-1 infection will provide useful information that will lead to new studies designed to enhance our understanding of the mechanistic roles of these molecules. In the present study, we focus on the utilization of D. melanogaster as a complementary system for studying HIV-1 related genes and proteins, why this research should be extended, and why this complementary system is an important method for enhancing our understanding of the genetics involved in HIV-1 infection.

KW - Analogous proteins

KW - Complementary system

KW - Transgenic lines

UR - http://www.scopus.com/inward/record.url?scp=20344363438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=20344363438&partnerID=8YFLogxK

U2 - 10.1002/jnr.20460

DO - 10.1002/jnr.20460

M3 - Short survey

C2 - 15795932

AN - SCOPUS:20344363438

VL - 80

SP - 451

EP - 455

JO - Journal of Neuroscience Research

JF - Journal of Neuroscience Research

SN - 0360-4012

IS - 4

ER -