Driving Simulator Performance in Charcot-Marie-Tooth Disease Type 1A

Nivedita U. Jerath, Nazan Aksan, Jeffrey D. Dawson, Matthew Rizzo, Ergun Y. Uc, Michael E. Shy

Research output: Contribution to journalArticle

Abstract

Introduction: This study evaluates driving ability in those with Charcot-Marie-Tooth Disease Type 1A, a hereditary peripheral neuropathy. Methods: Individuals with Charcot-Marie-Tooth Disease Type 1A (n = 18, age = 42 ± 7) and controls (n = 19; age = 35 ± 10) were evaluated in a driving simulator. The Charcot-Marie-Tooth Neuropathy Score version 2 was obtained for individuals. Rank Sum test and Spearman rank correlations were used for statistical analysis. Results: A 74% higher rate of lane departures and an 89% higher rate of lane deviations were seen in those with Charcot-Marie-Tooth Disease Type 1A than for controls (p = 0.005 and p < 0.001, respectively). Lane control variability was 10% higher for the individual group and correlated with the neuropathy score (rS = 0.518, p = 0.040), specifically sensory loss (rS = 0.710, p = 0.002) and pinprick sensation loss in the leg (rS = 0.490, p = 0.054). Discussion: Driving simulator assessment demonstrated more lane control errors in those with Charcot-Marie-Tooth Disease Type 1A, which correlated with lower extremity sensory loss. There was no significant difference in reported motor vehicle accidents.

Original languageEnglish (US)
JournalSAE International Journal of Transportation Safety
Volume7
Issue number1
DOIs
StatePublished - May 10 2019

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tooth disease
Simulators
performance
Statistical methods
Accidents
statistical analysis
motor vehicle
accident
ability

Keywords

  • Charcot-Marie-Tooth Disease Type 1A
  • Charcot-Marie-Tooth Neuropathy Score version 2
  • Driving simulator
  • Peripheral neuropathy
  • Sensory loss

ASJC Scopus subject areas

  • Human Factors and Ergonomics
  • Safety, Risk, Reliability and Quality
  • Safety Research
  • Mechanical Engineering

Cite this

Driving Simulator Performance in Charcot-Marie-Tooth Disease Type 1A. / Jerath, Nivedita U.; Aksan, Nazan; Dawson, Jeffrey D.; Rizzo, Matthew; Uc, Ergun Y.; Shy, Michael E.

In: SAE International Journal of Transportation Safety, Vol. 7, No. 1, 10.05.2019.

Research output: Contribution to journalArticle

Jerath, Nivedita U. ; Aksan, Nazan ; Dawson, Jeffrey D. ; Rizzo, Matthew ; Uc, Ergun Y. ; Shy, Michael E. / Driving Simulator Performance in Charcot-Marie-Tooth Disease Type 1A. In: SAE International Journal of Transportation Safety. 2019 ; Vol. 7, No. 1.
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