Drinking water and dietary sources of nitrate and nitrite and risk of glioma

Mary H. Ward, Ellen F. Heineman, Rodney D McComb, Dennis D. Weisenburger

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Objective: Dietary nitrite has been associated with increased glioma risk; however, drinking water nitrate has not been extensively evaluated. Methods: We conducted a population-based case-control study of adult glioma in Nebraska. Water utility nitrate measurements were linked to residential water source histories. We computed average nitrate exposure over a 20-year period. A food frequency questionnaire was used to assess dietary nitrate and nitrite. Results: Increasing quartiles of the average nitrate level in drinking water were not significantly associated with risk (adjusted odd ratios: 1.4, 1.2, 1.3). Risk was similar among those with both higher and lower intakes of vitamin C, an inhibitor of N-nitroso compound formation. Dietary nitrite intake was not associated with risk. Conclusions: Our study does not support a role for drinking water and dietary sources of nitrate and nitrite in risk of adult glioma.

Original languageEnglish (US)
Pages (from-to)1260-1267
Number of pages8
JournalJournal of occupational and environmental medicine
Volume47
Issue number12
DOIs
Publication statusPublished - Dec 2005

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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