Doxycycline effects on serum bone biomarkers in post-menopausal women

L. M. Golub, H. M. Lee, J. A. Stoner, Richard A Reinhardt, T. Sorsa, A. D. Goren, Jeffrey B Payne

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease progression, and biomarkers of collagen destruction and bone resorption locally in periodontal pockets, in a double-blind placebo-controlled clinical trial. We now hypothesize that SDD may also improve biomarkers of bone loss systemically in the same women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and animal models of bone-deficiency disease. 128 post-menopausal osteopenic women with chronic periodontitis randomly received SDD or placebo tablets daily for 2 years adjunctive to periodontal maintenance therapy every 3-4 months. Blood was collected at baseline and at one- and two-year appointments, and sera were analyzed for bone resorption and bone formation/turnover biomarkers. In subsets of the study population, adjunctive SDD significantly reduced serum biomarkers of bone resorption (biomarkers of bone formation were unaffected), consistent with reduced risk of future systemic bone loss in these post-menopausal women not yet on anti-osteoporotic drugs.

Original languageEnglish (US)
Pages (from-to)644-649
Number of pages6
JournalJournal of Dental Research
Volume89
Issue number6
DOIs
StatePublished - Jun 1 2010

Fingerprint

Doxycycline
Biomarkers
Bone and Bones
Bone Resorption
Serum
Osteogenesis
Placebos
Periodontal Pocket
Deficiency Diseases
Tetracyclines
Chronic Periodontitis
Bone Remodeling
Bone Diseases
Organ Culture Techniques
Controlled Clinical Trials
Periodontal Diseases
Tablets
Disease Progression
Appointments and Schedules
Collagen

Keywords

  • Osteopenia
  • Periodontitis
  • Post-menopause
  • Serum biomarkers
  • Subantimicrobial-dose-doxycycline

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Doxycycline effects on serum bone biomarkers in post-menopausal women. / Golub, L. M.; Lee, H. M.; Stoner, J. A.; Reinhardt, Richard A; Sorsa, T.; Goren, A. D.; Payne, Jeffrey B.

In: Journal of Dental Research, Vol. 89, No. 6, 01.06.2010, p. 644-649.

Research output: Contribution to journalArticle

Golub, L. M. ; Lee, H. M. ; Stoner, J. A. ; Reinhardt, Richard A ; Sorsa, T. ; Goren, A. D. ; Payne, Jeffrey B. / Doxycycline effects on serum bone biomarkers in post-menopausal women. In: Journal of Dental Research. 2010 ; Vol. 89, No. 6. pp. 644-649.
@article{20ebfc8ecb0c4bdc9df6173223c6aa4f,
title = "Doxycycline effects on serum bone biomarkers in post-menopausal women",
abstract = "We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease progression, and biomarkers of collagen destruction and bone resorption locally in periodontal pockets, in a double-blind placebo-controlled clinical trial. We now hypothesize that SDD may also improve biomarkers of bone loss systemically in the same women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and animal models of bone-deficiency disease. 128 post-menopausal osteopenic women with chronic periodontitis randomly received SDD or placebo tablets daily for 2 years adjunctive to periodontal maintenance therapy every 3-4 months. Blood was collected at baseline and at one- and two-year appointments, and sera were analyzed for bone resorption and bone formation/turnover biomarkers. In subsets of the study population, adjunctive SDD significantly reduced serum biomarkers of bone resorption (biomarkers of bone formation were unaffected), consistent with reduced risk of future systemic bone loss in these post-menopausal women not yet on anti-osteoporotic drugs.",
keywords = "Osteopenia, Periodontitis, Post-menopause, Serum biomarkers, Subantimicrobial-dose-doxycycline",
author = "Golub, {L. M.} and Lee, {H. M.} and Stoner, {J. A.} and Reinhardt, {Richard A} and T. Sorsa and Goren, {A. D.} and Payne, {Jeffrey B}",
year = "2010",
month = "6",
day = "1",
doi = "10.1177/0022034510363367",
language = "English (US)",
volume = "89",
pages = "644--649",
journal = "Journal of Dental Research",
issn = "0022-0345",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Doxycycline effects on serum bone biomarkers in post-menopausal women

AU - Golub, L. M.

AU - Lee, H. M.

AU - Stoner, J. A.

AU - Reinhardt, Richard A

AU - Sorsa, T.

AU - Goren, A. D.

AU - Payne, Jeffrey B

PY - 2010/6/1

Y1 - 2010/6/1

N2 - We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease progression, and biomarkers of collagen destruction and bone resorption locally in periodontal pockets, in a double-blind placebo-controlled clinical trial. We now hypothesize that SDD may also improve biomarkers of bone loss systemically in the same women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and animal models of bone-deficiency disease. 128 post-menopausal osteopenic women with chronic periodontitis randomly received SDD or placebo tablets daily for 2 years adjunctive to periodontal maintenance therapy every 3-4 months. Blood was collected at baseline and at one- and two-year appointments, and sera were analyzed for bone resorption and bone formation/turnover biomarkers. In subsets of the study population, adjunctive SDD significantly reduced serum biomarkers of bone resorption (biomarkers of bone formation were unaffected), consistent with reduced risk of future systemic bone loss in these post-menopausal women not yet on anti-osteoporotic drugs.

AB - We previously demonstrated that subantimicrobial-dose-doxycycline (SDD) treatment of post-menopausal osteopenic women significantly reduced periodontal disease progression, and biomarkers of collagen destruction and bone resorption locally in periodontal pockets, in a double-blind placebo-controlled clinical trial. We now hypothesize that SDD may also improve biomarkers of bone loss systemically in the same women, consistent with previous studies on tetracyclines (e.g., doxycycline) in organ culture and animal models of bone-deficiency disease. 128 post-menopausal osteopenic women with chronic periodontitis randomly received SDD or placebo tablets daily for 2 years adjunctive to periodontal maintenance therapy every 3-4 months. Blood was collected at baseline and at one- and two-year appointments, and sera were analyzed for bone resorption and bone formation/turnover biomarkers. In subsets of the study population, adjunctive SDD significantly reduced serum biomarkers of bone resorption (biomarkers of bone formation were unaffected), consistent with reduced risk of future systemic bone loss in these post-menopausal women not yet on anti-osteoporotic drugs.

KW - Osteopenia

KW - Periodontitis

KW - Post-menopause

KW - Serum biomarkers

KW - Subantimicrobial-dose-doxycycline

UR - http://www.scopus.com/inward/record.url?scp=77953264648&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953264648&partnerID=8YFLogxK

U2 - 10.1177/0022034510363367

DO - 10.1177/0022034510363367

M3 - Article

VL - 89

SP - 644

EP - 649

JO - Journal of Dental Research

JF - Journal of Dental Research

SN - 0022-0345

IS - 6

ER -