Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices

Marian Urban, Karen Booth, Stephan Schueler, Ivan Netuka, Guy MacGowan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.

Original languageEnglish (US)
JournalClinical Transplantation
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Statistical Factor Analysis
Transplantation
Transplants
Equipment and Supplies
Heart-Assist Devices
Tobacco Products
Cardiomyopathies
Craniocerebral Trauma
Proportional Hazards Models
Registries
Cause of Death
Cohort Studies
Prospective Studies
Hypertension

Keywords

  • donor characteristics
  • donor-recipient matching
  • heart transplantation
  • left ventricular assist device
  • mechanical assist device
  • recipient characteristics

ASJC Scopus subject areas

  • Transplantation

Cite this

Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices. / Urban, Marian; Booth, Karen; Schueler, Stephan; Netuka, Ivan; MacGowan, Guy.

In: Clinical Transplantation, 01.01.2018.

Research output: Contribution to journalArticle

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