Abstract
The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.
| Original language | English (US) |
|---|---|
| Article number | e13390 |
| Journal | Clinical Transplantation |
| Volume | 32 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2018 |
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Keywords
- donor characteristics
- donor-recipient matching
- heart transplantation
- left ventricular assist device
- mechanical assist device
- recipient characteristics
ASJC Scopus subject areas
- Transplantation
Cite this
Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices. / Urban, Marian; Booth, Karen; Schueler, Stephan; Netuka, Ivan; MacGowan, Guy.
In: Clinical Transplantation, Vol. 32, No. 10, e13390, 10.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices
AU - Urban, Marian
AU - Booth, Karen
AU - Schueler, Stephan
AU - Netuka, Ivan
AU - MacGowan, Guy
PY - 2018/10
Y1 - 2018/10
N2 - The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.
AB - The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N = 15 532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90 days and between 90 days and 5 years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P < 0.0001), recipient congenital (HR 2.7555, P < 0.0001) and ischemic (HR 1.165, P = 0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P = 0.0354) were predictors of death or graft failure within 90 days. Between 90 days and 5 years, donor cigarette use (HR 1.232, P = 0.0001), recipient cigarette use (HR 1.193, P = 0.0003), diabetes (HR 1.159, P = 0.0050), arterial hypertension (HR 1.129, P = 0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.
KW - donor characteristics
KW - donor-recipient matching
KW - heart transplantation
KW - left ventricular assist device
KW - mechanical assist device
KW - recipient characteristics
UR - http://www.scopus.com/inward/record.url?scp=85053479740&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053479740&partnerID=8YFLogxK
U2 - 10.1111/ctr.13390
DO - 10.1111/ctr.13390
M3 - Article
C2 - 30144327
AN - SCOPUS:85053479740
VL - 32
JO - Clinical Transplantation
JF - Clinical Transplantation
SN - 0902-0063
IS - 10
M1 - e13390
ER -