Does Vitamin E-Stabilized Ultrahigh-Molecular-Weight Polyethylene Address Concerns of Cross-Linked Polyethylene in Total Knee Arthroplasty?

Hani Haider, Joel N. Weisenburger, Steven M. Kurtz, Clare M. Rimnac, Jordan Freedman, David W. Schroeder, Kevin L. Garvin

Research output: Contribution to journalArticle

55 Scopus citations


Concerns about reduced strength, fatigue resistance, and oxidative stability of highly cross-linked and remelted ultrahigh-molecular-weight polyethylene (UHMWPE) have limited its clinical acceptance for total knee arthroplasty. We hypothesized that a highly cross-linked UHMWPE stabilized with vitamin E would have less oxidation and loss of mechanical properties. We compared the oxidation, in vitro strength, fatigue-crack propagation resistance, and wear of highly cross-linked UHMWPE doped with vitamin E to γ-inert-sterilized direct compression-molded UHMWPE (control). After accelerated aging, the control material showed elevated oxidation, loss of small-punch mechanical properties, and loss of fatigue-crack propagation resistance. In contrast, the vitamin E-stabilized material had minimal changes and exhibited 73% to 86% reduction in wear for both cruciate-retaining and posterior-stabilized total knee arthroplasty designs. Highly cross-linked vitamin E-stabilized UHMWPE performed well in vitro.

Original languageEnglish (US)
Pages (from-to)461-469
Number of pages9
JournalJournal of Arthroplasty
Issue number3
StatePublished - Mar 1 2012



  • Durability
  • Fatigue
  • TKA
  • Vitamin E
  • Wear

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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