Does transforming growth factor-β1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

Elizabeth S. Evans, Zafer Kocak, Su Min Zhou, Daniel A. Kahn, Hong Huang, Donna R. Hollis, Kim L. Light, Mitchell S. Anscher, Lawrence B. Marks

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-β1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade ≥ 1 RP, and 27 (22.3%) developed grade ≥ 2 RP. For the endpoint of grade ≥ 1 RP, those with V30 > 30% and an end-RT/baseline TGF-β1 ratio ≥ 1 had a significantly higher incidence of RP than did those with V30 > 30% and an end-RT/baseline TGF-β1 ratio < 1. For most other patient groups, there were no clear associations between TGF-β1 values and rates of RP. These findings suggest that TGF-β1 is generally not predictive for RP except for the group of patients with a high V30.

Original languageEnglish (US)
Pages (from-to)186-192
Number of pages7
JournalCytokine
Volume35
Issue number3-4
DOIs
StatePublished - Aug 1 2006

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Keywords

  • Radiation pneumonitis
  • TGF-β1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Hematology
  • Molecular Biology

Cite this

Evans, E. S., Kocak, Z., Zhou, S. M., Kahn, D. A., Huang, H., Hollis, D. R., Light, K. L., Anscher, M. S., & Marks, L. B. (2006). Does transforming growth factor-β1 predict for radiation-induced pneumonitis in patients treated for lung cancer? Cytokine, 35(3-4), 186-192. https://doi.org/10.1016/j.cyto.2006.07.021