Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy

Myron S. Cohen, Bradley E. Britigan, Daniel J. Hassett, Gerald M. Rosen

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Hydroxyl radical is a potent oxidizing agent of potential importance in human pathology. Since neutrophilic phagocytes make superoxide and hydrogen peroxide during phagocytosis, it has been proposed that hydroxyl radical is also formed. In this paper we review the literature which supports or refutes formation of hydroxyl radical by neutrophils and the mechanism(s) by which this radical migh be formed. We conclude that there is no definitive proof for hydroxyl radical formation by neutrophils. In fact, neutrophil release of lactoferrin and myeloperoxidase appears to limit formation of this radical. Future studies are likely to determine whether superoxide released by neutrophils interacts with target substrates to allow formation of hydroxyl radical.

Original languageEnglish (US)
Pages (from-to)81-88
Number of pages8
JournalFree Radical Biology and Medicine
Volume5
Issue number2
DOIs
StatePublished - 1988

Fingerprint

Hydroxyl Radical
Neutrophils
Superoxides
Lactoferrin
Pathology
Phagocytes
Phagocytosis
Oxidants
Hydrogen Peroxide
Peroxidase
Substrates

Keywords

  • Hydorxyl radical
  • Hydrogen peroxide
  • Iron
  • Lactoferrin
  • Myeloperoxidase
  • Neutrophils
  • Superoxide

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy. / Cohen, Myron S.; Britigan, Bradley E.; Hassett, Daniel J.; Rosen, Gerald M.

In: Free Radical Biology and Medicine, Vol. 5, No. 2, 1988, p. 81-88.

Research output: Contribution to journalArticle

Cohen, Myron S. ; Britigan, Bradley E. ; Hassett, Daniel J. ; Rosen, Gerald M. / Do humans neutrophils form hydroxyl radical? Evaluation of an unresolved controversy. In: Free Radical Biology and Medicine. 1988 ; Vol. 5, No. 2. pp. 81-88.
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