Acidic fibroblast growth factor (aFGF), basic fibroblast growth factor (bFGF), transforming growth factor alpha (TGF-α), transforming growth factor beta (TGF-ß), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF165), tumor necrosis factor alpha (TNF-α), and platelet-derived growth factor BB (PDGF-BB) were incorporated into slow release polymers and implanted in the rabbit cornea as an assay for angiogenesis activity. VEGF and low doses of PDGF-BB were direct angiogenesis factors, stimulating endothelial cells to form capillaries in the absence of inflammation. TGF-ß was an indirect angiogenesis factor, eliciting angiogenesis through the recruitment of inflammatory cell mediators. TGF-α and EGF were "bifunctional" angiogenesis factors. Both factors recruited inflammatory cells prior to angiogenesis, but when the inflammation was blocked, angiogenesis still proceeded. Acidic FGF, bFGF and TNF-α were non-angiogenic.
|Original language||English (US)|
|Number of pages||14|
|Publication status||Published - Jan 1 1997|
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