DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance

M. Furukawa, T. Harada, T. Tanaka, M. Kuwano

Research output: Contribution to journalReview article

Abstract

DNA topoisomerase(topo) I and II regulate the topological conformation and DNA molecules by catalyzing the concerted breakage of single or double strands. Topo I and II targeting anticancer agents such as camptothecins (CPT-II), epipodophyllotoxins (VP16 and VM26), and amsarcine are widely used in cancer chemotherapy. To enhance their therapeutic efficacies, one should understand how cellular sensitivities to these topo-targeting agents are regulated, and one should also understand what mechanisms or factors are involved in the appearance of tumor cells resistant to them. We will discuss if there is any marker useful for determining drug sensitivity to these topo-targeting agents in cancer cells.

Original languageEnglish (US)
Pages (from-to)1096-1102
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Volume55
Issue number5
StatePublished - May 1997

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DNA Topoisomerases
Drug Resistance
Antineoplastic Agents
Podophyllotoxin
Carnitine O-Palmitoyltransferase
Nucleic Acid Conformation
Camptothecin
Neoplasms
Type II DNA Topoisomerase
Type I DNA Topoisomerase
Drug Therapy
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance. / Furukawa, M.; Harada, T.; Tanaka, T.; Kuwano, M.

In: Nippon rinsho. Japanese journal of clinical medicine, Vol. 55, No. 5, 05.1997, p. 1096-1102.

Research output: Contribution to journalReview article

Furukawa, M. ; Harada, T. ; Tanaka, T. ; Kuwano, M. / DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance. In: Nippon rinsho. Japanese journal of clinical medicine. 1997 ; Vol. 55, No. 5. pp. 1096-1102.
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