DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance

M. Furukawa, T. Harada, T. Tanaka, M. Kuwano

Research output: Contribution to journalReview article


DNA topoisomerase(topo) I and II regulate the topological conformation and DNA molecules by catalyzing the concerted breakage of single or double strands. Topo I and II targeting anticancer agents such as camptothecins (CPT-II), epipodophyllotoxins (VP16 and VM26), and amsarcine are widely used in cancer chemotherapy. To enhance their therapeutic efficacies, one should understand how cellular sensitivities to these topo-targeting agents are regulated, and one should also understand what mechanisms or factors are involved in the appearance of tumor cells resistant to them. We will discuss if there is any marker useful for determining drug sensitivity to these topo-targeting agents in cancer cells.

Original languageEnglish (US)
Pages (from-to)1096-1102
Number of pages7
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number5
Publication statusPublished - May 1997


ASJC Scopus subject areas

  • Medicine(all)

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