DNA methylation of viruses infecting a eukaryotic Chlorella-like green alga

James L. van Etten, Anne M. Schuster, Lois Girton, Dwight E. Burbank, David Swinton, Stanley Hattman

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Abstract

The genomic DNAs of the eukaryotic Chlorella-like green alga, strain NC64A, and eleven of its viruses all contain significant levels of 5-methyldeoxycytidine. In addition, the host DNA as well as six of the viral DNAs also contain N6-methyldeoxyadenosine. At least some of the methylated bases in the host reside in different base sequences than the nethylated bases in the viruses as shown by differential susceptibility to restriction endonuclease enzymes. This suggests that the viruses encode for DNA methyltransferases with sequence specificities different from that of the host enzyme.

Original languageEnglish (US)
Pages (from-to)3471-3478
Number of pages8
JournalNucleic acids research
Volume13
Issue number10
DOIs
Publication statusPublished - May 24 1985

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ASJC Scopus subject areas

  • Genetics

Cite this

van Etten, J. L., Schuster, A. M., Girton, L., Burbank, D. E., Swinton, D., & Hattman, S. (1985). DNA methylation of viruses infecting a eukaryotic Chlorella-like green alga. Nucleic acids research, 13(10), 3471-3478. https://doi.org/10.1093/nar/13.10.3471