Divergent Selection for Heat Loss in Mice: I. Selection Applied and Direct Response Through Fifteen Generations

M. K. Nielsen, L. D. Jones, B. A. Freking, J. A. DeShazer

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Divergent selection for heat production/loss (kcal·kg-.75·d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Repeatability of the heat loss measurement was .45 and the CV was 10.5%. Cumulative realized selection differentials, averaged for the three replicates, were 145.1 and -105.0 (kcal·kg-.75·d-1) and ranged from 136.9 to 149.2 and -107.1 to -101.3 for MH and ML selection, respectively. Cumulative standardized realized selection differentials, averaged for the three replicates, were 10.06 and -9.51 for MH and ML selection, respectively. Direct responses (kcal·kg-.75·d-1) in heat loss after 15 generations were 44.2 for MH and -27.4 for ML as deviations from MC. Asymmetry of response was evident (P = .03) by Generation 10. Realized heritability was .28 ± .01 based on divergence of MH and ML selection. For selection for higher and lower heat loss, realized heritabilities were .31 ± .01 and .26 ± .01, respectively.

Original languageEnglish (US)
Pages (from-to)1461-1468
Number of pages8
JournalJournal of animal science
Volume75
Issue number6
DOIs
StatePublished - Jun 1997

Fingerprint

Hot Temperature
heat
mice
heritability
calorimeters
Thermogenesis
heat production
repeatability
animals

Keywords

  • Energy Metabolism
  • Heat Loss
  • Mice
  • Selection

ASJC Scopus subject areas

  • Food Science
  • Animal Science and Zoology
  • Genetics

Cite this

Divergent Selection for Heat Loss in Mice : I. Selection Applied and Direct Response Through Fifteen Generations. / Nielsen, M. K.; Jones, L. D.; Freking, B. A.; DeShazer, J. A.

In: Journal of animal science, Vol. 75, No. 6, 06.1997, p. 1461-1468.

Research output: Contribution to journalArticle

Nielsen, M. K. ; Jones, L. D. ; Freking, B. A. ; DeShazer, J. A. / Divergent Selection for Heat Loss in Mice : I. Selection Applied and Direct Response Through Fifteen Generations. In: Journal of animal science. 1997 ; Vol. 75, No. 6. pp. 1461-1468.
@article{fee8692004af4c45a383b0600e19decb,
title = "Divergent Selection for Heat Loss in Mice: I. Selection Applied and Direct Response Through Fifteen Generations",
abstract = "Divergent selection for heat production/loss (kcal·kg-.75·d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Repeatability of the heat loss measurement was .45 and the CV was 10.5{\%}. Cumulative realized selection differentials, averaged for the three replicates, were 145.1 and -105.0 (kcal·kg-.75·d-1) and ranged from 136.9 to 149.2 and -107.1 to -101.3 for MH and ML selection, respectively. Cumulative standardized realized selection differentials, averaged for the three replicates, were 10.06 and -9.51 for MH and ML selection, respectively. Direct responses (kcal·kg-.75·d-1) in heat loss after 15 generations were 44.2 for MH and -27.4 for ML as deviations from MC. Asymmetry of response was evident (P = .03) by Generation 10. Realized heritability was .28 ± .01 based on divergence of MH and ML selection. For selection for higher and lower heat loss, realized heritabilities were .31 ± .01 and .26 ± .01, respectively.",
keywords = "Energy Metabolism, Heat Loss, Mice, Selection",
author = "Nielsen, {M. K.} and Jones, {L. D.} and Freking, {B. A.} and DeShazer, {J. A.}",
year = "1997",
month = "6",
doi = "10.2527/1997.7561461x",
language = "English (US)",
volume = "75",
pages = "1461--1468",
journal = "Journal of Animal Science",
issn = "0021-8812",
publisher = "American Society of Animal Science",
number = "6",

}

TY - JOUR

T1 - Divergent Selection for Heat Loss in Mice

T2 - I. Selection Applied and Direct Response Through Fifteen Generations

AU - Nielsen, M. K.

AU - Jones, L. D.

AU - Freking, B. A.

AU - DeShazer, J. A.

PY - 1997/6

Y1 - 1997/6

N2 - Divergent selection for heat production/loss (kcal·kg-.75·d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Repeatability of the heat loss measurement was .45 and the CV was 10.5%. Cumulative realized selection differentials, averaged for the three replicates, were 145.1 and -105.0 (kcal·kg-.75·d-1) and ranged from 136.9 to 149.2 and -107.1 to -101.3 for MH and ML selection, respectively. Cumulative standardized realized selection differentials, averaged for the three replicates, were 10.06 and -9.51 for MH and ML selection, respectively. Direct responses (kcal·kg-.75·d-1) in heat loss after 15 generations were 44.2 for MH and -27.4 for ML as deviations from MC. Asymmetry of response was evident (P = .03) by Generation 10. Realized heritability was .28 ± .01 based on divergence of MH and ML selection. For selection for higher and lower heat loss, realized heritabilities were .31 ± .01 and .26 ± .01, respectively.

AB - Divergent selection for heat production/loss (kcal·kg-.75·d-1), measured in 9- to 11-wk-old male mice, was conducted for 15 generations. Heat loss was measured for 15 h on individual animals placed overnight in direct, gradient-layer calorimeters. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Repeatability of the heat loss measurement was .45 and the CV was 10.5%. Cumulative realized selection differentials, averaged for the three replicates, were 145.1 and -105.0 (kcal·kg-.75·d-1) and ranged from 136.9 to 149.2 and -107.1 to -101.3 for MH and ML selection, respectively. Cumulative standardized realized selection differentials, averaged for the three replicates, were 10.06 and -9.51 for MH and ML selection, respectively. Direct responses (kcal·kg-.75·d-1) in heat loss after 15 generations were 44.2 for MH and -27.4 for ML as deviations from MC. Asymmetry of response was evident (P = .03) by Generation 10. Realized heritability was .28 ± .01 based on divergence of MH and ML selection. For selection for higher and lower heat loss, realized heritabilities were .31 ± .01 and .26 ± .01, respectively.

KW - Energy Metabolism

KW - Heat Loss

KW - Mice

KW - Selection

UR - http://www.scopus.com/inward/record.url?scp=0031159076&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031159076&partnerID=8YFLogxK

U2 - 10.2527/1997.7561461x

DO - 10.2527/1997.7561461x

M3 - Article

C2 - 9250505

AN - SCOPUS:0031159076

VL - 75

SP - 1461

EP - 1468

JO - Journal of Animal Science

JF - Journal of Animal Science

SN - 0021-8812

IS - 6

ER -