Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma

Isabel Valverde, Henry M. Lemon, Anne Kessinger, Roger H. Unger

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Gel filtration of plasma from a patient with a clinical synDr.ome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so-called “big plasma glucagon” (BPG) measured 190 pg/ml (normal average 113 ± 79 pg/ml, Mean ± SD, N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 ± 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 ± 29 pg/ml); and the small glucagon immunoreactive fraction (-2000 mol wt) measured 35 pg/ml (normal average 26 ± 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.

Original languageEnglish (US)
Pages (from-to)804-808
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume42
Issue number5
DOIs
StatePublished - Jan 1 1976

Fingerprint

Glucagonoma
Glucagon
Plasmas
Proglucagon
Gel Chromatography
Tumors
Gels

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma. / Valverde, Isabel; Lemon, Henry M.; Kessinger, Anne; Unger, Roger H.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 42, No. 5, 01.01.1976, p. 804-808.

Research output: Contribution to journalArticle

Valverde, Isabel ; Lemon, Henry M. ; Kessinger, Anne ; Unger, Roger H. / Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma. In: Journal of Clinical Endocrinology and Metabolism. 1976 ; Vol. 42, No. 5. pp. 804-808.
@article{9ea6e8c5c63149518b69a74fd797e6f4,
title = "Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma",
abstract = "Gel filtration of plasma from a patient with a clinical synDr.ome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so-called “big plasma glucagon” (BPG) measured 190 pg/ml (normal average 113 ± 79 pg/ml, Mean ± SD, N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 ± 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 ± 29 pg/ml); and the small glucagon immunoreactive fraction (-2000 mol wt) measured 35 pg/ml (normal average 26 ± 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.",
author = "Isabel Valverde and Lemon, {Henry M.} and Anne Kessinger and Unger, {Roger H.}",
year = "1976",
month = "1",
day = "1",
doi = "10.1210/jcem-42-5-804",
language = "English (US)",
volume = "42",
pages = "804--808",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "5",

}

TY - JOUR

T1 - Distribution of plasma glucagon immunoreactivity in a patient with suspected glucagonoma

AU - Valverde, Isabel

AU - Lemon, Henry M.

AU - Kessinger, Anne

AU - Unger, Roger H.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - Gel filtration of plasma from a patient with a clinical synDr.ome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so-called “big plasma glucagon” (BPG) measured 190 pg/ml (normal average 113 ± 79 pg/ml, Mean ± SD, N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 ± 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 ± 29 pg/ml); and the small glucagon immunoreactive fraction (-2000 mol wt) measured 35 pg/ml (normal average 26 ± 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.

AB - Gel filtration of plasma from a patient with a clinical synDr.ome of glucagonoma and a total plasma glucagon level of 2600 pg/ml, revealed the four glucagon immunoreactive fractions found in normal subjects. The total hyperglucagonemia observed was due to high levels of true glucagon and proglucagon moieties. The so-called “big plasma glucagon” (BPG) measured 190 pg/ml (normal average 113 ± 79 pg/ml, Mean ± SD, N = 10); the large glucagon immunoreactivity, LGI (9000 mol wt), measured 625 pg/ml (normal average 11 ± 16 pg/ml); the true glucagon accounted for 1435 pg/ml (normal average 31 ± 29 pg/ml); and the small glucagon immunoreactive fraction (-2000 mol wt) measured 35 pg/ml (normal average 26 ± 18 pg/ml). The high levels of LGI, considered a candidate for proglucagon, may reflect the increased secretory activity of the tumor.

UR - http://www.scopus.com/inward/record.url?scp=0017179444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017179444&partnerID=8YFLogxK

U2 - 10.1210/jcem-42-5-804

DO - 10.1210/jcem-42-5-804

M3 - Article

C2 - 178682

AN - SCOPUS:0017179444

VL - 42

SP - 804

EP - 808

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 5

ER -