Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein

J. M. Foidart, E. W. Bere, M. Yaar, S. I. Rennard, M. Gullino, G. R. Martin, S. I. Katz

Research output: Contribution to journalArticle

367 Citations (Scopus)

Abstract

Laminin is a noncollagenous glycoprotein isolated from a transplantable mouse tumor producing basement membrane (BM). Purified antibodies to laminin do not cross-react with other known BM antigens including type IV collagen, fibronectin, bullous pemphigoid antigen, and a BM proteoglycan. Using immunofluorescence, laminin is localized in the BM zones of those human, chick, guinea pig, bovine, monkey, rat, and mouse tissues examined. Epithelial and endothelial cells in culture synthesize laminin while mesenchymal cells do not. By immunoelectron microscopy, laminin was localized to the lamina lucida of human epidermal BM and of mouse esophagus epithelial BM. The wide distribution of laminin among diverse tissues and species, and in early stages of embryonic development, suggests that laminin is a ubiquitous component of basement membranes.

Original languageEnglish (US)
Pages (from-to)336-342
Number of pages7
JournalLaboratory Investigation
Volume42
Issue number3
StatePublished - Jul 25 1980

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Membrane Glycoproteins
Laminin
Basement Membrane
Antigens
Bullous Pemphigoid
Collagen Type IV
Immunoelectron Microscopy
Proteoglycans
Fibronectins
Esophagus
Embryonic Development
Haplorhini
Fluorescent Antibody Technique
Glycoproteins
Guinea Pigs
Endothelial Cells
Cell Culture Techniques
Epithelial Cells
Antibodies
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Foidart, J. M., Bere, E. W., Yaar, M., Rennard, S. I., Gullino, M., Martin, G. R., & Katz, S. I. (1980). Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Laboratory Investigation, 42(3), 336-342.

Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. / Foidart, J. M.; Bere, E. W.; Yaar, M.; Rennard, S. I.; Gullino, M.; Martin, G. R.; Katz, S. I.

In: Laboratory Investigation, Vol. 42, No. 3, 25.07.1980, p. 336-342.

Research output: Contribution to journalArticle

Foidart, JM, Bere, EW, Yaar, M, Rennard, SI, Gullino, M, Martin, GR & Katz, SI 1980, 'Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein', Laboratory Investigation, vol. 42, no. 3, pp. 336-342.
Foidart JM, Bere EW, Yaar M, Rennard SI, Gullino M, Martin GR et al. Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Laboratory Investigation. 1980 Jul 25;42(3):336-342.
Foidart, J. M. ; Bere, E. W. ; Yaar, M. ; Rennard, S. I. ; Gullino, M. ; Martin, G. R. ; Katz, S. I. / Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. In: Laboratory Investigation. 1980 ; Vol. 42, No. 3. pp. 336-342.
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