Dissociation of Therapeutic and Toxic Effects of Polyinosinic-Polycytidylic Acid Admixed with Poly-L-lysine and Solubilized with Carboxymethyl Cellulose in Tumor-bearing Mice

Diethelm Hartmann, Joanne S. Adams, Alan K. Meeker, Mark A. Schneider, Barbara F. Lenz, James E. Talmadge

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

In this paper, we describe a study of the therapeutic parameters (dose and schedule) and immunomodulatory activity (macrophage, natural killer cell, and T-cell number and function) of polyinosinic-polycytidylic acid admixed with poly-L-lysine and solubilized with carboxymethyl cellulose [poly(l,C)-LC] in the treatment of MBL-2 tumor ascites. Tumor-bearing mice received an optimal therapeutic protocol [100 µg poly(l,C)-LC administered twice a wk], a maximum tolerated dose [50 µg poly(l,C)-LC administered daily], or the optimal immunomodulatory protocol for normal mice [10 µg poly(l,C)-LC administered daily]. The percentage of tumor-associated macrophages and their cytotoxic activity correlated with host survival. In addition, splenic T-cell activity correlated with host survival, and splenic natural killer cell function had a near significant correlation with host survival. These results indicate that the optimal dose and schedule of poly(l,C)-LC for immunomodulation in tumor-bearing animals are also the optimal therapeutic protocol but have less toxicity than the maximum tolerated dose.

Original languageEnglish (US)
Pages (from-to)1331-1338
Number of pages8
JournalCancer Research
Volume46
Issue number3
StatePublished - Mar 1 1986

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Poly C
Poly I-C
Carboxymethylcellulose Sodium
Poisons
Therapeutic Uses
Lysine
Maximum Tolerated Dose
Neoplasms
Natural Killer Cells
Appointments and Schedules
Macrophages
T-Lymphocytes
Immunomodulation
Therapeutics
Ascites
Cell Count

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dissociation of Therapeutic and Toxic Effects of Polyinosinic-Polycytidylic Acid Admixed with Poly-L-lysine and Solubilized with Carboxymethyl Cellulose in Tumor-bearing Mice. / Hartmann, Diethelm; Adams, Joanne S.; Meeker, Alan K.; Schneider, Mark A.; Lenz, Barbara F.; Talmadge, James E.

In: Cancer Research, Vol. 46, No. 3, 01.03.1986, p. 1331-1338.

Research output: Contribution to journalArticle

Hartmann, Diethelm ; Adams, Joanne S. ; Meeker, Alan K. ; Schneider, Mark A. ; Lenz, Barbara F. ; Talmadge, James E. / Dissociation of Therapeutic and Toxic Effects of Polyinosinic-Polycytidylic Acid Admixed with Poly-L-lysine and Solubilized with Carboxymethyl Cellulose in Tumor-bearing Mice. In: Cancer Research. 1986 ; Vol. 46, No. 3. pp. 1331-1338.
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